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10.1093/ndt/gfp390 http://scihub22266oqcxt.onion/10.1093/ndt/gfp390 19666912!ä!19666912 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephrol+Dial+Transplant 2010 ; 25 (1): 129-36 Nephropedia Template TP {{tp|p=19666912|t=2010. Early versus late start of immunosuppressive therapy in idiopathic membranous nephropathy: a randomized controlled trial |pdf=|usr=}}{{19666912}} gab.com Text Early versus late start of immunosuppressive therapy in idiopathic membranous nephropathy: a randomized controlled trial JO: Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=19666912 #FOAvip BACKGROUND: Immunosuppressive therapy in idiopathic membranous nephropathy (iMN) is debated. Accurate identification of patients at high risk for end-stage renal disease (ESRD) allows early start of therapy in these patients. It is unknown if early start of therapy is more effective and/or less toxic than late start (i.e. when GFR deteriorates). METHODS: We conducted a randomized open-label study in patients with iMN, a normal renal function and a high risk for ESRD (urinary beta2m >0.5 microg/min, UIgG >125 mg/day). Patients started with immunosuppressive therapy (cyclophosphamide for 12 months, and steroids) either immediately after randomization or when renal function deteriorated (DeltasCr > or =+25% and sCr >135 micromol/l or DeltasCr > or =+50%). End points were remission rates, duration of the nephrotic syndrome (NS), renal function and complications. RESULTS: The study included 26 patients (24 M/2 F), age 48 +/- 12 years; sCr 96 micromol/l (range 68-126) and median proteinuria 10.0 g/10 mmol Cr. Early treatment resulted in a more rapid onset of remission (P = 0.003) and a shorter duration of the NS (P = 0.009). However, at the end of the follow-up (72 +/- 22 m), there were no differences in overall remission rate, sCr (93 versus 105 micromol/l), proteinuria, relapse rate and adverse events. CONCLUSIONS: In high-risk patients with iMN, immunosuppressive treatment is effective in inducing a remission. Early treatment shortens the duration of the nephrotic phase, but does not result in better preservation of renal function. Our study indicates that treatment decisions must be based on risk and benefit assessment in the individual patient. Twit Text FOAVip Early versus late start of immunosuppressive therapy in idiopathic membranous nephropathy: a randomized controlled trial ????Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=19666912 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19666912 #FOAvip English Wikipedia <ref>{{Cite pmid|19666912}}</ref> Early versus late start of immunosuppressive therapy in idiopathic membranous nephropathy: a randomized controlled trial #MMPMID19666912 Hofstra JM; Branten AJ; Wirtz JJ; Noordzij TC; du Buf-Vereijken PW; Wetzels JF Nephrol Dial Transplant 2010[Jan]; 25 (1): 129-36 PMID19666912show ga BACKGROUND: Immunosuppressive therapy in idiopathic membranous nephropathy (iMN) is debated. Accurate identification of patients at high risk for end-stage renal disease (ESRD) allows early start of therapy in these patients. It is unknown if early start of therapy is more effective and/or less toxic than late start (i.e. when GFR deteriorates). METHODS: We conducted a randomized open-label study in patients with iMN, a normal renal function and a high risk for ESRD (urinary beta2m >0.5 microg/min, UIgG >125 mg/day). Patients started with immunosuppressive therapy (cyclophosphamide for 12 months, and steroids) either immediately after randomization or when renal function deteriorated (DeltasCr > or =+25% and sCr >135 micromol/l or DeltasCr > or =+50%). End points were remission rates, duration of the nephrotic syndrome (NS), renal function and complications. RESULTS: The study included 26 patients (24 M/2 F), age 48 +/- 12 years; sCr 96 micromol/l (range 68-126) and median proteinuria 10.0 g/10 mmol Cr. Early treatment resulted in a more rapid onset of remission (P = 0.003) and a shorter duration of the NS (P = 0.009). However, at the end of the follow-up (72 +/- 22 m), there were no differences in overall remission rate, sCr (93 versus 105 micromol/l), proteinuria, relapse rate and adverse events. CONCLUSIONS: In high-risk patients with iMN, immunosuppressive treatment is effective in inducing a remission. Early treatment shortens the duration of the nephrotic phase, but does not result in better preservation of renal function. Our study indicates that treatment decisions must be based on risk and benefit assessment in the individual patient. |Adult[MESH] |Cyclophosphamide/*administration & dosage/adverse effects/*therapeutic use[MESH] |Drug Administration Schedule[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Glomerulonephritis, Membranous/*drug therapy/physiopathology[MESH] |Humans[MESH] |Immunosuppressive Agents/*administration & dosage/adverse effects/*therapeutic use[MESH] |Kidney Failure, Chronic/epidemiology/physiopathology[MESH] |Kidney/physiopathology[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |Remission Induction[MESH] |Risk Assessment[MESH] |Risk Factors[MESH]Early versus late start of immunosuppressive therapy in idiopathic mem(epmc).pdf DeepDyve Pubget Overpricing