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10.1248/bpb.32.1359 http://scihub22266oqcxt.onion/10.1248/bpb.32.1359 19652374!ä!19652374 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Pharm+Bull 2009 ; 32 (8): 1359-63 Nephropedia Template TP {{tp|p=19652374|t=2009. Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride |pdf=|usr=}}{{19652374}} gab.com Text Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride JO: Biol Pharm Bull http://www.kidney.de/pget.php?&tw=1&pmid=19652374 #FOAvip Salidroside is a major constituent of Rhodiola rosea L. that elicits beneficial effects for ischemic cardiovascular diseases. The aim of this study was to investigate the protective effects of salidroside on endothelial cells apoptosis induced by the hypoxia mimicking agent, cobalt chloride. After challenge with cobalt chloride for 24 h, loss of cell viability and excessive apoptotic cell death were observed in EA.hy926 endothelial cells, and the level of intracellular reactive oxygen species (ROS) increased concentration-dependently. However, the endothelial cell apoptosis and excessive ROS generation were attenuated markedly by salidroside pretreatment. In addition, salidroside inhibited activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) induced by cobalt chloride, decreased expression of Bax and rescued the balance of pro- and anti-apoptotic proteins. These findings suggest that salidroside protects endothelial cells from cobalt chloride-induced apoptosis as an antioxidant and by regulating Bcl-2 family. Salidroside may represent a novel therapeutic agent for the treatment and prevention of hypoxia and oxidative stress-related diseases. Twit Text FOAVip Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride ????Biol Pharm Bull http://www.kidney.de/pget.php?&tw=1&pmid=19652374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19652374 #FOAvip English Wikipedia <ref>{{Cite pmid|19652374}}</ref> Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride #MMPMID19652374 Tan CB; Gao M; Xu WR; Yang XY; Zhu XM; Du GH Biol Pharm Bull 2009[Aug]; 32 (8): 1359-63 PMID19652374show ga Salidroside is a major constituent of Rhodiola rosea L. that elicits beneficial effects for ischemic cardiovascular diseases. The aim of this study was to investigate the protective effects of salidroside on endothelial cells apoptosis induced by the hypoxia mimicking agent, cobalt chloride. After challenge with cobalt chloride for 24 h, loss of cell viability and excessive apoptotic cell death were observed in EA.hy926 endothelial cells, and the level of intracellular reactive oxygen species (ROS) increased concentration-dependently. However, the endothelial cell apoptosis and excessive ROS generation were attenuated markedly by salidroside pretreatment. In addition, salidroside inhibited activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) induced by cobalt chloride, decreased expression of Bax and rescued the balance of pro- and anti-apoptotic proteins. These findings suggest that salidroside protects endothelial cells from cobalt chloride-induced apoptosis as an antioxidant and by regulating Bcl-2 family. Salidroside may represent a novel therapeutic agent for the treatment and prevention of hypoxia and oxidative stress-related diseases. |Antioxidants/chemistry/*pharmacology[MESH] |Apoptosis/*drug effects[MESH] |Blotting, Western[MESH] |Caspase 3/biosynthesis/metabolism[MESH] |Cell Culture Techniques[MESH] |Cell Hypoxia/drug effects[MESH] |Cell Line[MESH] |Cell Survival/drug effects[MESH] |Cobalt/*toxicity[MESH] |Dose-Response Relationship, Drug[MESH] |Endothelial Cells/*drug effects/metabolism/pathology[MESH] |Endothelium, Vascular/*drug effects/metabolism/pathology[MESH] |Flow Cytometry[MESH] |Glucosides/chemistry/*pharmacology[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis[MESH] |Molecular Structure[MESH] |Phenols/chemistry/*pharmacology[MESH] |Proto-Oncogene Proteins c-bcl-2/biosynthesis[MESH] |Reactive Oxygen Species/metabolism[MESH]Protective effects of salidroside on endothelial cell apoptosis induce(epmc).pdf DeepDyve Pubget Overpricing