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10.1354/vp.08-VP-0229-P-FL http://scihub22266oqcxt.onion/10.1354/vp.08-VP-0229-P-FL 19605916!ä!19605916 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vet+Pathol 2009 ; 46 (6): 1187-96 Nephropedia Template TP {{tp|p=19605916|t=2009. Canine influenza virus replicates in alveolar macrophages and induces TNF-alpha |pdf=|usr=}}{{19605916}} gab.com Text Canine influenza virus replicates in alveolar macrophages and induces TNF-alpha JO: Vet Pathol http://www.kidney.de/pget.php?&tw=1&pmid=19605916 #FOAvip Canine influenza virus (CIV) is a recently emergent pathogen of dogs that has caused highly contagious respiratory disease in racing Greyhounds, pet dogs, and shelter animals. Initial characterizations of CIV-induced respiratory disease suggested alveolar macrophages may be susceptible to virus infection. To investigate the role of the alveolar macrophage in the pathogenesis of CIV infection, primary alveolar macrophages were inoculated with CIV and studied from 0 to 48 hours later. Virus titers in alveolar macrophage culture supernatants increased significantly (P < .05, n = 7) from 3 to 24 hours following virus inoculation. Virus matrix gene expression was significantly increased (P < .05, n = 14) at 3, 6, and 12 hours after inoculation, peaking at 6,445-fold the level of RNA detectable immediately following inoculation. Virus-inoculated macrophages demonstrated significantly (P < .05, n = 5) decreased viability (30% trypan blue positive) by 12 hours after inoculation compared with mock-inoculated cells (5% trypan blue positive). By 12 hours after inoculation, tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) mRNA levels were significantly (P < .05, n = 11) increased over those immediately following inoculation. Only TNF-alpha protein levels were significantly increased (P < .05, n = 11) at 12 hours after inoculation. In conclusion, the results indicate that CIV replicates in canine alveolar macrophages and induces TNF-alpha expression and cell death. Twit Text FOAVip Canine influenza virus replicates in alveolar macrophages and induces TNF-alpha ????Vet Pathol http://www.kidney.de/pget.php?&tw=1&pmid=19605916 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19605916 #FOAvip English Wikipedia <ref>{{Cite pmid|19605916}}</ref> Canine influenza virus replicates in alveolar macrophages and induces TNF-alpha #MMPMID19605916 Powe JR; Castleman WL Vet Pathol 2009[Nov]; 46 (6): 1187-96 PMID19605916show ga Canine influenza virus (CIV) is a recently emergent pathogen of dogs that has caused highly contagious respiratory disease in racing Greyhounds, pet dogs, and shelter animals. Initial characterizations of CIV-induced respiratory disease suggested alveolar macrophages may be susceptible to virus infection. To investigate the role of the alveolar macrophage in the pathogenesis of CIV infection, primary alveolar macrophages were inoculated with CIV and studied from 0 to 48 hours later. Virus titers in alveolar macrophage culture supernatants increased significantly (P < .05, n = 7) from 3 to 24 hours following virus inoculation. Virus matrix gene expression was significantly increased (P < .05, n = 14) at 3, 6, and 12 hours after inoculation, peaking at 6,445-fold the level of RNA detectable immediately following inoculation. Virus-inoculated macrophages demonstrated significantly (P < .05, n = 5) decreased viability (30% trypan blue positive) by 12 hours after inoculation compared with mock-inoculated cells (5% trypan blue positive). By 12 hours after inoculation, tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) mRNA levels were significantly (P < .05, n = 11) increased over those immediately following inoculation. Only TNF-alpha protein levels were significantly increased (P < .05, n = 11) at 12 hours after inoculation. In conclusion, the results indicate that CIV replicates in canine alveolar macrophages and induces TNF-alpha expression and cell death. |Animals[MESH] |Cell Death[MESH] |Dogs[MESH] |Gene Expression Regulation/physiology[MESH] |Influenza A Virus, H3N8 Subtype/*physiology[MESH] |Macrophages, Alveolar/*virology[MESH] |RNA, Messenger/genetics/metabolism[MESH] |Tumor Necrosis Factor-alpha/genetics/*metabolism[MESH]Canine influenza virus replicates in alveolar macrophages and induces (epmc).pdf DeepDyve Pubget Overpricing