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10.1152/ajprenal.00159.2009 http://scihub22266oqcxt.onion/10.1152/ajprenal.00159.2009 19474192!3350128!19474192     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2009 ; 297 (4): F838-48 Nephropedia Template TP {{tp|p=19474192|t=2009. The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs |pdf=|usr=}}{{19474192}} gab.com Text The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=19474192 #FOAvip The thiazide-sensitive Na+-Cl(-) cotransporter is the major salt reabsorption pathway in the distal convoluted tubule, which is located just after the macula densa at the beginning of the aldosterone-sensitive nephron. This cotransporter was identified at the molecular level in the early 1990s by the pioneering work of Steven C. Hebert and coworkers, opening the molecular area, not only for the Na+-Cl(-) cotransporter but also for the family of electroneutral cation-coupled chloride cotransporters that includes the loop diuretic-sensitive Na+-K+-2Cl(-) cotransporter of the thick ascending limb of Henle's loop. This work honoring the memory of Steve Hebert presents a brief review of our current knowledge about salt and water homeostasis generated as a consequence of cloning the cotransporter, with particular emphasis on the molecular biology, physiological properties, human disease due to decreased or increased activity of the cotransporter, and regulation of the cotransporter by a family of serine/threonine kinases known as WNK. Thus one of the legacies of Steve Hebert is a better understanding of salt and water homeostasis. Twit Text FOAVip The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=19474192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19474192 #FOAvip English Wikipedia <ref>{{Cite pmid|19474192}}</ref> The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs #MMPMID19474192 Gamba G Am J Physiol Renal Physiol 2009[Oct]; 297 (4): F838-48 PMID19474192show ga The thiazide-sensitive Na+-Cl(-) cotransporter is the major salt reabsorption pathway in the distal convoluted tubule, which is located just after the macula densa at the beginning of the aldosterone-sensitive nephron. This cotransporter was identified at the molecular level in the early 1990s by the pioneering work of Steven C. Hebert and coworkers, opening the molecular area, not only for the Na+-Cl(-) cotransporter but also for the family of electroneutral cation-coupled chloride cotransporters that includes the loop diuretic-sensitive Na+-K+-2Cl(-) cotransporter of the thick ascending limb of Henle's loop. This work honoring the memory of Steve Hebert presents a brief review of our current knowledge about salt and water homeostasis generated as a consequence of cloning the cotransporter, with particular emphasis on the molecular biology, physiological properties, human disease due to decreased or increased activity of the cotransporter, and regulation of the cotransporter by a family of serine/threonine kinases known as WNK. Thus one of the legacies of Steve Hebert is a better understanding of salt and water homeostasis. |*Homeostasis[MESH] |Animals[MESH] |Humans[MESH] |Kidney Diseases/metabolism[MESH] |Kidney Tubules/*metabolism[MESH] |Protein Serine-Threonine Kinases/*metabolism[MESH] |Receptors, Drug/*metabolism[MESH] |Sodium Chloride Symporters/*metabolism[MESH] |Sodium Chloride/*metabolism[MESH]The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, funct(epmc).pdf DeepDyve Pubget Overpricing