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10.1086/599042

http://scihub22266oqcxt.onion/10.1086/599042
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19441978!ä!19441978

suck abstract from ncbi


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pmid19441978      Clin+Infect+Dis 2009 ; 48 (12): 1713-23
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  • Neurologic manifestations associated with parvovirus B19 infection #MMPMID19441978
  • Douvoyiannis M; Litman N; Goldman DL
  • Clin Infect Dis 2009[Jun]; 48 (12): 1713-23 PMID19441978show ga
  • Eighty-one cases of neurologic disease, including encephalitis, meningitis, stroke, and peripheral neuropathy, that were associated with parvovirus B19 infection were reviewed. Most patients were children, and two-thirds had central nervous system manifestations. One-third had altered immunity. Viral symptoms (odds ratio [OR], 5.7; P= .002), rash (OR, 11.5; P< .001), and peripheral nervous system involvement (OR, 12.1; P= .004) were more frequent in immunocompetent patients. Brain magnetic resonance imaging abnormalities were more frequent in patients with altered immunity (OR, 10; P= .04). In central nervous system disease, parvovirus B19 DNA was commonly detected in cerebrospinal fluid (81% of samples) and serum (85%), whereas specific antibodies were found in 33% of cerebrospinal fluid samples. Neurologic sequelae occurred in 22% of 77 patients with a known outcome, and some improvement occurred in 16%. No differences in the prevalence of sequealae were noted between immunocompetent patients (21% of whom experienced sequealae) and patients with altered immunity (25%) or between patients with central nervous system manifestations who received intravenous immunoglobulin with or without steroids and those patients with central nervous system manifestations who did not. Five patients died.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Central Nervous System Diseases/diagnosis/*epidemiology/mortality/virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Parvoviridae Infections/*complications/*virology[MESH]
  • |Parvovirus B19, Human/*isolation & purification[MESH]
  • |Peripheral Nervous System Diseases/diagnosis/*epidemiology/virology[MESH]
  • |Prevalence[MESH]
  • |Treatment Outcome[MESH]


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