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10.1016/j.cbi.2009.05.002 http://scihub22266oqcxt.onion/10.1016/j.cbi.2009.05.002 19433077!ä!19433077 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Biol+Interact 2009 ; 180 (3): 454-9 Nephropedia Template TP {{tp|p=19433077|t=2009. Modulation of haloperidol induced electrophysiological alterations on cardiac action potential by various risk factors and gender difference |pdf=|usr=}}{{19433077}} gab.com Text Modulation of haloperidol induced electrophysiological alterations on cardiac action potential by various risk factors and gender difference JO: Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=19433077 #FOAvip Haloperidol (HPL), well known antipsychotic drug can induce a marked QT prolongation and polymorphic arrhythmias. In this study we evaluated the influence of various induced risk factors such as electrolyte imbalance (hypokalemia and hypomagnesemia), gender difference, low pacing frequency, ischemia reperfusion insult on electrophysiological effect by haloperidol on electrically driven action potentials recorded from guinea pig papillary muscle. The doses of HPL ranging from 1 to 16 microM were used in this investigation. Action potentials (APs) were elicited electrically and recorded by classical microelectrode technique. HPL caused dose dependent prolongation of APD(90) the final stage of repolarization, increased triangulation, and led into dispersion of action potential, conduction delay and conduction block. Magnitude of the effect of haloperidol was amplified significantly by most of the risk factors. Among the various risk factors, electrolyte imbalance (hypokalemia, hypomagnesemia) caused more amplification of HPL effect. Most of the risk factors amplified prolongation of APD(90) by HPL. This effect is mainly due to the influence of these electrolytes and sex hormone on various ion channels involved in the repolarization phase of cardiac AP. This is the first report which provides an experimental evidence of amplification of electrophysiological effects of HPL in the presence of various risk factors. Twit Text FOAVip Modulation of haloperidol induced electrophysiological alterations on cardiac action potential by various risk factors and gender difference ????Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=19433077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19433077 #FOAvip English Wikipedia <ref>{{Cite pmid|19433077}}</ref> Modulation of haloperidol induced electrophysiological alterations on cardiac action potential by various risk factors and gender difference #MMPMID19433077 Raghu KG; Singh R; Prathapan A; Yadav GK Chem Biol Interact 2009[Aug]; 180 (3): 454-9 PMID19433077show ga Haloperidol (HPL), well known antipsychotic drug can induce a marked QT prolongation and polymorphic arrhythmias. In this study we evaluated the influence of various induced risk factors such as electrolyte imbalance (hypokalemia and hypomagnesemia), gender difference, low pacing frequency, ischemia reperfusion insult on electrophysiological effect by haloperidol on electrically driven action potentials recorded from guinea pig papillary muscle. The doses of HPL ranging from 1 to 16 microM were used in this investigation. Action potentials (APs) were elicited electrically and recorded by classical microelectrode technique. HPL caused dose dependent prolongation of APD(90) the final stage of repolarization, increased triangulation, and led into dispersion of action potential, conduction delay and conduction block. Magnitude of the effect of haloperidol was amplified significantly by most of the risk factors. Among the various risk factors, electrolyte imbalance (hypokalemia, hypomagnesemia) caused more amplification of HPL effect. Most of the risk factors amplified prolongation of APD(90) by HPL. This effect is mainly due to the influence of these electrolytes and sex hormone on various ion channels involved in the repolarization phase of cardiac AP. This is the first report which provides an experimental evidence of amplification of electrophysiological effects of HPL in the presence of various risk factors. |Action Potentials/*drug effects[MESH] |Animals[MESH] |Antipsychotic Agents/*toxicity[MESH] |Arrhythmias, Cardiac/chemically induced[MESH] |Electrolytes/metabolism[MESH] |Female[MESH] |Gonadal Steroid Hormones/metabolism[MESH] |Guinea Pigs[MESH] |Haloperidol/*toxicity[MESH] |Ion Channels/metabolism[MESH] |Male[MESH] |Microelectrodes[MESH] |Papillary Muscles/drug effects[MESH] |Risk Factors[MESH]Modulation of haloperidol induced electrophysiological alterations on (epmc).pdf DeepDyve Pubget Overpricing