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10.1099/vir.0.011841-0 http://scihub22266oqcxt.onion/10.1099/vir.0.011841-0 19420156!ä!19420156 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2009 ; 90 (Pt 8): 1932-1936 Nephropedia Template TP {{tp|p=19420156|t=2009. Second-site mutations in Borna disease virus overexpressing viral accessory protein X |pdf=|usr=}}{{19420156}} gab.com Text Second-site mutations in Borna disease virus overexpressing viral accessory protein X JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=19420156 #FOAvip The X protein of Borna disease virus (BDV) is an essential factor that regulates viral polymerase activity and inhibits apoptosis of persistently infected cells. We observed that a BDV mutant which carries an additional X gene replicated well in cell culture only after acquiring second-site mutations that selectively reduced expression of the endogenous X gene. In rat brains, the virus acquired additional mutations which inactivated the ectopic X gene or altered the sequence of X. These results demonstrate that BDV readily acquires mutations if strong selection pressure is applied. They further indicate that fine-tuning of X expression determines viral fitness. Twit Text FOAVip Second-site mutations in Borna disease virus overexpressing viral accessory protein X ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=19420156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19420156 #FOAvip English Wikipedia <ref>{{Cite pmid|19420156}}</ref> Second-site mutations in Borna disease virus overexpressing viral accessory protein X #MMPMID19420156 Poenisch M; Wille S; Schneider U; Staeheli P J Gen Virol 2009[Aug]; 90 (Pt 8): 1932-1936 PMID19420156show ga The X protein of Borna disease virus (BDV) is an essential factor that regulates viral polymerase activity and inhibits apoptosis of persistently infected cells. We observed that a BDV mutant which carries an additional X gene replicated well in cell culture only after acquiring second-site mutations that selectively reduced expression of the endogenous X gene. In rat brains, the virus acquired additional mutations which inactivated the ectopic X gene or altered the sequence of X. These results demonstrate that BDV readily acquires mutations if strong selection pressure is applied. They further indicate that fine-tuning of X expression determines viral fitness. |*Gene Dosage[MESH] |*Gene Expression Regulation, Viral[MESH] |*Mutation, Missense[MESH] |Animals[MESH] |Borna disease virus/genetics/*physiology[MESH] |Brain/virology[MESH] |DNA Mutational Analysis[MESH] |Gene Knockout Techniques[MESH] |Rats[MESH] |Sequence Analysis, DNA[MESH] |Viral Regulatory and Accessory Proteins/*biosynthesis/*genetics[MESH]Second-site mutations in Borna disease virus overexpressing viral acce(epmc).pdf DeepDyve Pubget Overpricing