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pmid1940357      J+Immunol 1991 ; 147 (10): 3581-6
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  • Transforming growth factor-beta modulates T cell-mediated encephalitis caused by Borna disease virus Pathogenic importance of CD8+ cells and suppression of antibody formation #MMPMID1940357
  • Stitz L; Planz O; Bilzer T; Frei K; Fontana A
  • J Immunol 1991[Nov]; 147 (10): 3581-6 PMID1940357show ga
  • Borna disease is a virus-induced, immune-mediated encephalomyelitis based on a delayed-type hypersensitivity reaction. The severity of clinical symptoms after intracerebral infection of rats with Borna disease virus was reduced after treatment with transforming growth factor (TGF-beta 2). Intraperitoneal injection of the recombinant molecule, rTGF-beta 2, started on the day of infection at a dose of either 1 micrograms given every day or every other day for 8 consecutive days or 2 micrograms every third day, was found to result in the absence of typical Borna disease symptoms at 14 days after infection in most of the TGF-beta-treated rats, a time point at which all infected control animals not treated with rTGF-beta 2 showed distinct signs of Borna disease. The inhibition of the disease was paralleled by a significant reduction of the inflammatory reaction in the brain. However, the efficacy of treatment with rTGF-beta 2 was transient, because after day 21 only a slight or no reduction of the inflammatory reaction and, consequently, symptoms of Borna disease could be observed. Immunohistologic investigations revealed reduced CD4+ T cell numbers and no changes in macrophage counts in encephalitic lesions of rTG-beta treated rats. However, CD8+ cells were markedly decreased in the encephalitic lesions. Furthermore, the expression of MHC class II Ag was significantly reduced in the brain of rTGF-beta 2 treated Borna disease virus-infected rats, whereas MHC class I Ag expression was not. Most treated animals showed a reduction of Borna disease virus-specific serum antibodies, the result of an inhibition of the IgG response. The results presented here suggest a distinct influence of rTGF-beta 2 on T cell-mediated immune functions during the early phase of Borna disease virus-induced encephalomyelitis.
  • |Animals[MESH]
  • |Antigens, Viral/analysis[MESH]
  • |Borna Disease/*immunology/pathology/therapy[MESH]
  • |Borna disease virus/immunology[MESH]
  • |Brain/*immunology/microbiology/pathology[MESH]
  • |CD8 Antigens/analysis[MESH]
  • |Encephalitis/*immunology/pathology/therapy[MESH]
  • |Hippocampus/pathology[MESH]
  • |Hypersensitivity, Delayed/immunology/therapy[MESH]
  • |Immunity, Cellular/drug effects[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Lew[MESH]
  • |T-Lymphocyte Subsets/*immunology[MESH]


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