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10.1016/j.bbr.2009.04.010 http://scihub22266oqcxt.onion/10.1016/j.bbr.2009.04.010 19379776/?report=reader!2735613!19379776     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Behav+Brain+Res 2009 ; 204 (2): 274-81 Nephropedia Template TP {{tp|p=19379776|t=2009. Animal models of gene-environment interactions in schizophrenia |pdf=|usr=}}{{19379776}} gab.com Text Animal models of gene-environment interactions in schizophrenia JO: Behav Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=19379776 #FOAvip The pathogenesis of schizophrenia and related mental illnesses likely involves multiple interactions between susceptibility genes of small effects and environmental factors. Gene-environment interactions occur across different stages of neurodevelopment to produce heterogeneous clinical and pathological manifestations of the disease. The main obstacle for mechanistic studies of gene-environment interplay has been the paucity of appropriate experimental systems for elucidating the molecular pathways that mediate gene-environment interactions relevant to schizophrenia. Recent advances in psychiatric genetics and a plethora of experimental data from animal studies allow us to suggest a new approach to gene-environment interactions in schizophrenia. We propose that animal models based on identified genetic mutations and measurable environment factors will help advance studies of the molecular mechanisms of gene-environment interplay. Twit Text FOAVip Animal models of gene-environment interactions in schizophrenia ????Behav Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=19379776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19379776 #FOAvip English Wikipedia <ref>{{Cite pmid|19379776}}</ref> Animal models of gene-environment interactions in schizophrenia #MMPMID19379776 Ayhan Y; Sawa A; Ross CA; Pletnikov MV Behav Brain Res 2009[Dec]; 204 (2): 274-81 PMID19379776show ga The pathogenesis of schizophrenia and related mental illnesses likely involves multiple interactions between susceptibility genes of small effects and environmental factors. Gene-environment interactions occur across different stages of neurodevelopment to produce heterogeneous clinical and pathological manifestations of the disease. The main obstacle for mechanistic studies of gene-environment interplay has been the paucity of appropriate experimental systems for elucidating the molecular pathways that mediate gene-environment interactions relevant to schizophrenia. Recent advances in psychiatric genetics and a plethora of experimental data from animal studies allow us to suggest a new approach to gene-environment interactions in schizophrenia. We propose that animal models based on identified genetic mutations and measurable environment factors will help advance studies of the molecular mechanisms of gene-environment interplay. |*Disease Models, Animal[MESH] |Animals[MESH] |Brain/physiopathology[MESH] |Cell Adhesion Molecules, Neuronal/genetics[MESH] |Environment[MESH] |Extracellular Matrix Proteins/genetics[MESH] |Gene Expression Regulation[MESH] |Genetic Predisposition to Disease[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Nerve Tissue Proteins/genetics[MESH] |Neuregulin-1/genetics[MESH] |Neurogenesis[MESH] |Phenotype[MESH] |Rats[MESH] |Reelin Protein[MESH] |Schizophrenia/*genetics[MESH]Animal models of gene-environment interactions in schizophrenia (epmc).pdf DeepDyve Pubget Overpricing