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10.1016/j.cca.2009.04.002

http://scihub22266oqcxt.onion/10.1016/j.cca.2009.04.002
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19362081!ä!19362081

suck abstract from ncbi


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pmid19362081      Clin+Chim+Acta 2009 ; 405 (1-2): 76-82
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  • Anti-human parvovirus B19 nonstructural protein antibodies in patients with rheumatoid arthritis #MMPMID19362081
  • Tzang BS; Tsai CC; Tsay GJ; Wang M; Sun YS; Hsu TC
  • Clin Chim Acta 2009[Jul]; 405 (1-2): 76-82 PMID19362081show ga
  • BACKGROUND: Previous studies have reported the association between the development of NS1-specific IgG and arthropathy after the infection of human parvovirus B19 (B19). However, the role of anti-B19-NS1 IgG in RA is still unclear. This study investigated the role of anti-B19-NS1 antibody in patients with rheumatoid arthritis (RA). METHODS: B19-VP IgM and IgG antibodies, nested PCR, B19-NS1 IgM and IgG antibodies, and anti-cyclic citrullinated peptide (CCP) antibodies were assessed by ELISA and Western blot in this study. RESULTS: Significantly higher prevalence of B19-NS1 IgM and IgG antibodies in patients with recent B19 infection was observed as well as the higher prevalence of B19-NS1 IgM and IgG antibodies in RA patients with seronegative diagnostic patterns. However, no significant variation of both B19-NS1 IgM and IgG was detected in RA patients with different B19 diagnostic patterns. Additionally, significantly higher presence of anti-CCP IgG was observed in RA patients with B19-NS1 IgM. CONCLUSIONS: This study suggests the possibility of anti-B19-NS1 IgM as an indicator for RA diagnosis and indicates the suspense of the higher prevalence of anti-B19-NS1 antibody in RA patients with seronegative B19 diagnostic patterns. However, these results provide clues in understanding the association of anti-B19-NS1 antibody in RA patients.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Arthritis, Rheumatoid/blood/complications/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mutation/genetics[MESH]
  • |Parvoviridae Infections/blood/complications/diagnosis/*immunology[MESH]
  • |Parvovirus B19, Human/*immunology[MESH]


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