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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell 2009 ; 137 (1): 32-45 Nephropedia Template TP
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The vertebrate primary cilium in development, homeostasis, and disease #MMPMID19345185
Gerdes JM; Davis EE; Katsanis N
Cell 2009[Apr]; 137 (1): 32-45 PMID19345185show ga
Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.