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10.1111/j.1360-0443.2009.02504.x http://scihub22266oqcxt.onion/10.1111/j.1360-0443.2009.02504.x 19335651/?report=reader!2703791!19335651     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addiction 2009 ; 104 (4): 518-32 Nephropedia Template TP {{tp|p=19335651|t=2009. Candidate genes for cannabis use disorders: findings, challenges and directions |pdf=|usr=}}{{19335651}} gab.com Text Candidate genes for cannabis use disorders: findings, challenges and directions JO: Addiction http://www.kidney.de/pget.php?&tw=1&pmid=19335651 #FOAvip AIM: Twin studies have shown that cannabis use disorders (abuse/dependence) are highly heritable. This review aims to: (i) review existing linkage studies of cannabis use disorders and (ii) review gene association studies, to identify potential candidate genes, including those that have been tested for composite substance use disorders and (iii) to highlight challenges in the genomic study of cannabis use disorders. METHODS: Peer-reviewed linkage and candidate gene association studies are reviewed. RESULTS: Four linkage studies are reviewed: results from these have homed in on regions on chromosomes 1, 3, 4, 9, 14, 17 and 18, which harbor candidates of predicted biological relevance, such as monoglyceride lipase (MGLL) on chromosome 3, but also novel genes, including ELTD1[epidermal growth factor (EGF), latrophilin and seven transmembrane domain containing 1] on chromosome 1. Gene association studies are presented for (a) genes posited to have specific influences on cannabis use disorders: CNR1, CB2, FAAH, MGLL, TRPV1 and GPR55 and (b) genes from various neurotransmitter systems that are likely to exert a non-specific influence on risk of cannabis use disorders, e.g. GABRA2, DRD2 and OPRM1. CONCLUSIONS: There are challenges associated with (i) understanding biological complexity underlying cannabis use disorders (including the need to study gene-gene and gene-environment interactions), (ii) using diagnostic versus quantitative phenotypes, (iii) delineating which stage of cannabis involvement (e.g. use versus misuse) genes influence and (iv) problems of sample ascertainment. Twit Text FOAVip Candidate genes for cannabis use disorders: findings, challenges and directions ????Addiction http://www.kidney.de/pget.php?&tw=1&pmid=19335651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19335651 #FOAvip English Wikipedia <ref>{{Cite pmid|19335651}}</ref> Candidate genes for cannabis use disorders: findings, challenges and directions #MMPMID19335651 Agrawal A; Lynskey MT Addiction 2009[Apr]; 104 (4): 518-32 PMID19335651show ga AIM: Twin studies have shown that cannabis use disorders (abuse/dependence) are highly heritable. This review aims to: (i) review existing linkage studies of cannabis use disorders and (ii) review gene association studies, to identify potential candidate genes, including those that have been tested for composite substance use disorders and (iii) to highlight challenges in the genomic study of cannabis use disorders. METHODS: Peer-reviewed linkage and candidate gene association studies are reviewed. RESULTS: Four linkage studies are reviewed: results from these have homed in on regions on chromosomes 1, 3, 4, 9, 14, 17 and 18, which harbor candidates of predicted biological relevance, such as monoglyceride lipase (MGLL) on chromosome 3, but also novel genes, including ELTD1[epidermal growth factor (EGF), latrophilin and seven transmembrane domain containing 1] on chromosome 1. Gene association studies are presented for (a) genes posited to have specific influences on cannabis use disorders: CNR1, CB2, FAAH, MGLL, TRPV1 and GPR55 and (b) genes from various neurotransmitter systems that are likely to exert a non-specific influence on risk of cannabis use disorders, e.g. GABRA2, DRD2 and OPRM1. CONCLUSIONS: There are challenges associated with (i) understanding biological complexity underlying cannabis use disorders (including the need to study gene-gene and gene-environment interactions), (ii) using diagnostic versus quantitative phenotypes, (iii) delineating which stage of cannabis involvement (e.g. use versus misuse) genes influence and (iv) problems of sample ascertainment. |Diseases in Twins/*genetics[MESH] |Genetic Linkage/genetics[MESH] |Genotype[MESH] |Humans[MESH] |Marijuana Abuse/*genetics[MESH] |Receptors, Estrogen/*genetics[MESH]Candidate genes for cannabis use disorders: findings, challenges and d(epmc).pdf DeepDyve Pubget Overpricing