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10.1111/j.1462-5822.2009.01310.x

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suck abstract from ncbi


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pmid19290912      Cell+Microbiol 2009 ; 11 (6): 872-9
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  • Borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways #MMPMID19290912
  • Planz O; Pleschka S; Wolff T
  • Cell Microbiol 2009[Jun]; 11 (6): 872-9 PMID19290912show ga
  • Borna disease virus (BDV) is a neurotropic RNA virus that establishes non-cytolytic persistent infection in the central nervous system of warm-blooded animals. Depending on the host species and the route of infection, BDV persistence can modulate neuronal plasticity and animal behaviour and/or may provoke a T cell-mediated immunopathological reaction with high mortality. Therefore, BDV functions as a model pathogen to study persistent virus infection in the central nervous system. Here, we review recent evidence showing that BDV interferes with a spectrum of intracellular signalling pathways, which may be involved in viral spread, maintenance of persistence and modulation of neurotransmitter pathways.
  • |*Host-Pathogen Interactions[MESH]
  • |*Signal Transduction[MESH]
  • |Animals[MESH]
  • |Borna disease virus/*immunology/*pathogenicity[MESH]


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