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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Microbiol 2009 ; 11 (6): 872-9 Nephropedia Template TP
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Borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways #MMPMID19290912
Planz O; Pleschka S; Wolff T
Cell Microbiol 2009[Jun]; 11 (6): 872-9 PMID19290912show ga
Borna disease virus (BDV) is a neurotropic RNA virus that establishes non-cytolytic persistent infection in the central nervous system of warm-blooded animals. Depending on the host species and the route of infection, BDV persistence can modulate neuronal plasticity and animal behaviour and/or may provoke a T cell-mediated immunopathological reaction with high mortality. Therefore, BDV functions as a model pathogen to study persistent virus infection in the central nervous system. Here, we review recent evidence showing that BDV interferes with a spectrum of intracellular signalling pathways, which may be involved in viral spread, maintenance of persistence and modulation of neurotransmitter pathways.