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10.1159/000208212

http://scihub22266oqcxt.onion/10.1159/000208212
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19276629!2881330!19276629
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suck abstract from ncbi

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  • Primary cilia and signaling pathways in mammalian development, health and disease #MMPMID19276629
  • Veland IR; Awan A; Pedersen LB; Yoder BK; Christensen ST
  • Nephron Physiol 2009[]; 111 (3): p39-53 PMID19276629show ga
  • Although first described as early as 1898 and long considered a vestigial organelle of little functional importance, the primary cilium has become one of the hottest research topics in modern cell biology and physiology. Primary cilia are nonmotile sensory organelles present in a single copy on the surface of most growth-arrested or differentiated mammalian cells, and defects in their assembly or function are tightly coupled to many developmental defects, diseases and disorders. In normal tissues, the primary cilium coordinates a series of signal transduction pathways, including Hedgehog, Wnt, PDGFRalpha and integrin signaling. In the kidney, the primary cilium may function as a mechano-, chemo- and osmosensing unit that probes the extracellular environment and transmits signals to the cell via, e.g., polycystins, which depend on ciliary localization for appropriate function. Indeed, hypomorphic mutations in the mouse ift88 (previously called Tg737) gene, which encodes a ciliogenic intraflagellar transport protein, result in malformation of primary cilia, and in the collecting ducts of kidney tubules this is accompanied by development of autosomal recessive polycystic kidney disease (PKD). While PKD was one of the first diseases to be linked to dysfunctional primary cilia, defects in this organelle have subsequently been associated with many other phenotypes, including cancer, obesity, diabetes as well as a number of developmental defects. Collectively, these disorders of the cilium are now referred to as the ciliopathies. In this review, we provide a brief overview of the structure and function of primary cilia and some of their roles in coordinating signal transduction pathways in mammalian development, health and disease.
  • |*Signal Transduction[MESH]
  • |Animals[MESH]
  • |Cilia/*metabolism/pathology[MESH]
  • |Embryonic Development[MESH]
  • |Humans[MESH]
  • |Intracellular Signaling Peptides and Proteins/*metabolism[MESH]
  • |Kidney/metabolism/pathology[MESH]
  • |Mutation[MESH]
  • |Polycystic Kidney Diseases/metabolism/pathology[MESH]
  • |Stem Cells/metabolism/pathology[MESH]
  • |Tumor Suppressor Proteins/genetics/metabolism[MESH]


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  • suck abstract from ncbi

    p39 3.111 2009