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10.1007/s00228-009-0626-7 http://scihub22266oqcxt.onion/10.1007/s00228-009-0626-7 19229529!ä!19229529 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Clin+Pharmacol 2009 ; 65 (5): 465-72 Nephropedia Template TP {{tp|p=19229529|t=2009. Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis |pdf=|usr=}}{{19229529}} gab.com Text Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis JO: Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=19229529 #FOAvip BACKGROUND: Resistance to high-dose loop diuretics can be overcome either by co-administration with thiazides or by treatment with medium-dose loop diuretics combined with thiazides. Combination therapy has been proven to be superior to high-dose loop diuretic monotherapy for cardiac and renal edema. However, such a strongly efficacious short-term regimen is often complicated by undesired effects, including circulatory collapse and electrolyte disturbances. The question of whether the loop diuretic/thiazide combinations are efficacious and safe when conventional doses are combined has not yet been answered. METHODS: The effects of hydrochlorothiazide (HCT) and torasemide (TO) given alone on the excretion of Na+, Cl-, K+, Mg2+, and Ca2+ were compared with the effects of combined administration of the diuretics in 12 healthy volunteers. RESULTS: The co-administration of HCT (25 mg) with TO (5 or 10 mg) strongly increased Na+ excretion. However, the combination significantly reduced K+ and Mg2+ excretion. The K+-sparing effect of the HCT/TO combination was shown to be due to a significant reduction in the HCT-induced increase in fractional K+ excretion by the loop diuretic. Total excretion of Ca2+ relative to Na+ excretion was less with the HCT/TO combination than with TO given alone. CONCLUSION: The enhancement of desired NaCl excretion by the HCT/TO combination with significant reduction of undesired loss of K+ and Mg2+ meets clinical requirements but has to be validated in long-term clinical trials. Twit Text FOAVip Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis ????Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=19229529 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19229529 #FOAvip English Wikipedia <ref>{{Cite pmid|19229529}}</ref> Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis #MMPMID19229529 Knauf H; Mutschler E; Velazquez H; Giebisch G Eur J Clin Pharmacol 2009[May]; 65 (5): 465-72 PMID19229529show ga BACKGROUND: Resistance to high-dose loop diuretics can be overcome either by co-administration with thiazides or by treatment with medium-dose loop diuretics combined with thiazides. Combination therapy has been proven to be superior to high-dose loop diuretic monotherapy for cardiac and renal edema. However, such a strongly efficacious short-term regimen is often complicated by undesired effects, including circulatory collapse and electrolyte disturbances. The question of whether the loop diuretic/thiazide combinations are efficacious and safe when conventional doses are combined has not yet been answered. METHODS: The effects of hydrochlorothiazide (HCT) and torasemide (TO) given alone on the excretion of Na+, Cl-, K+, Mg2+, and Ca2+ were compared with the effects of combined administration of the diuretics in 12 healthy volunteers. RESULTS: The co-administration of HCT (25 mg) with TO (5 or 10 mg) strongly increased Na+ excretion. However, the combination significantly reduced K+ and Mg2+ excretion. The K+-sparing effect of the HCT/TO combination was shown to be due to a significant reduction in the HCT-induced increase in fractional K+ excretion by the loop diuretic. Total excretion of Ca2+ relative to Na+ excretion was less with the HCT/TO combination than with TO given alone. CONCLUSION: The enhancement of desired NaCl excretion by the HCT/TO combination with significant reduction of undesired loss of K+ and Mg2+ meets clinical requirements but has to be validated in long-term clinical trials. |Adult[MESH] |Diuretics/*pharmacology/therapeutic use[MESH] |Dose-Response Relationship, Drug[MESH] |Drug Combinations[MESH] |Female[MESH] |Humans[MESH] |Hydrochlorothiazide/administration & dosage/*pharmacology/therapeutic use[MESH] |Magnesium/urine[MESH] |Male[MESH] |Middle Aged[MESH] |Natriuresis/*drug effects[MESH] |Potassium/urine[MESH] |Sulfonamides/administration & dosage/*pharmacology/therapeutic use[MESH] |Thiazides/administration & dosage/*pharmacology/therapeutic use[MESH]Torasemide significantly reduces thiazide-induced potassium and magnes(epmc).pdf DeepDyve Pubget Overpricing