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10.1089/jir.2008.0050 http://scihub22266oqcxt.onion/10.1089/jir.2008.0050 19203244!ä!19203244 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Interferon+Cytokine+Res 2009 ; 29 (4): 199-207 Nephropedia Template TP {{tp|p=19203244|t=2009. Differential regulation of the OASL and OAS1 genes in response to viral infections |pdf=|usr=}}{{19203244}} gab.com Text Differential regulation of the OASL and OAS1 genes in response to viral infections JO: J Interferon Cytokine Res http://www.kidney.de/pget.php?&tw=1&pmid=19203244 #FOAvip The 2'-5' oligoadenylate synthetase (OAS) family consist of three genes encoding active OAS enzymes (OAS1-3) and an OAS-Like (OASL) gene encoding an inactive protein. The transcription of all four members of this family is actively induced by interferon (IFN), but so far no attempt to systematically analyze the expression of these genes during viral infection has been made. We analyzed the expression of the human OAS1 and OASL genes in response to infection with Sendai virus or Influenza A virus. Surprisingly, we found a marked difference in the expression pattern of these genes. Our data showed that the OASL gene is rapidly induced in response to viral infection and that this induction is mediated by IFN regulatory factor 3 (IRF-3). In contrast to the OASL gene, the induction of the OAS1 gene by virus infection was lower, and did require a functional type I IFN response. The pronounced difference in gene regulation between the OAS1 and OASL genes agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein. Furthermore, the behavior of the OASL gene is consistent with the behavior of an antiviral gene. Twit Text FOAVip Differential regulation of the OASL and OAS1 genes in response to viral infections ????J Interferon Cytokine Res http://www.kidney.de/pget.php?&tw=1&pmid=19203244 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19203244 #FOAvip English Wikipedia <ref>{{Cite pmid|19203244}}</ref> Differential regulation of the OASL and OAS1 genes in response to viral infections #MMPMID19203244 Melchjorsen J; Kristiansen H; Christiansen R; Rintahaka J; Matikainen S; Paludan SR; Hartmann R J Interferon Cytokine Res 2009[Apr]; 29 (4): 199-207 PMID19203244show ga The 2'-5' oligoadenylate synthetase (OAS) family consist of three genes encoding active OAS enzymes (OAS1-3) and an OAS-Like (OASL) gene encoding an inactive protein. The transcription of all four members of this family is actively induced by interferon (IFN), but so far no attempt to systematically analyze the expression of these genes during viral infection has been made. We analyzed the expression of the human OAS1 and OASL genes in response to infection with Sendai virus or Influenza A virus. Surprisingly, we found a marked difference in the expression pattern of these genes. Our data showed that the OASL gene is rapidly induced in response to viral infection and that this induction is mediated by IFN regulatory factor 3 (IRF-3). In contrast to the OASL gene, the induction of the OAS1 gene by virus infection was lower, and did require a functional type I IFN response. The pronounced difference in gene regulation between the OAS1 and OASL genes agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein. Furthermore, the behavior of the OASL gene is consistent with the behavior of an antiviral gene. |*Gene Expression Regulation/immunology[MESH] |2',5'-Oligoadenylate Synthetase/*genetics/immunology[MESH] |Cell Line[MESH] |Cell Line, Tumor[MESH] |Humans[MESH] |Influenza A virus/immunology/*physiology[MESH] |Interferon Type I/immunology[MESH] |Macrophages/immunology/virology[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH]Differential regulation of the OASL and OAS1 genes in response to vira(epmc).pdf DeepDyve Pubget Overpricing