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10.1208/s12249-008-9183-0 http://scihub22266oqcxt.onion/10.1208/s12249-008-9183-0 19184450StudiesonMefenamicAcidMicroparticles:FormulationInVitroReleaseandInSituStudiesinRats.!2663673!19184450     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+PharmSciTech 2009 ; 10 (1): 104-12 Nephropedia Template TP {{tp|p=19184450|t=2009. Studies on mefenamic acid microparticles: formulation, in vitro release, and in situ studies in rats |pdf=|usr=}}{{19184450}} gab.com Text Studies on mefenamic acid microparticles: formulation, in vitro release, and in situ studies in rats JO: AAPS PharmSciTech http://www.kidney.de/pget.php?&tw=1&pmid=19184450 #FOAvip In this study, we investigated the in vitro characteristics of mefenamic acid (MA) microparticles as well as their effects on DNA damage. MA-loaded chitosan and alginate beads were prepared by the ionotropic gelation process. Microsponges containing MA and Eudragit RS 100 were prepared by quasi-emulsion solvent diffusion method. The microparticles were characterized in terms of particle size, surface morphology, encapsulation efficiency, and in vitro release profiles. Most of the formulation variables manifested an influence on the physical characteristics of the microparticles at varying degrees. We also studied the effects of MA, MA-loaded microparticles, and three different polymers on rat brain cortex DNA damage. Our results showed that DNA damage was higher in MA-loaded Eudragit microsponges than MA-loaded biodegradable chitosan or alginate microparticles. Twit Text FOAVip Studies on mefenamic acid microparticles: formulation, in vitro release, and in situ studies in rats ????AAPS PharmSciTech http://www.kidney.de/pget.php?&tw=1&pmid=19184450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19184450 #FOAvip English Wikipedia <ref>{{Cite pmid|19184450}}</ref> Studies on mefenamic acid microparticles: formulation, in vitro release, and in situ studies in rats #MMPMID19184450 Sevgi F; Yurdasiper A; Kaynarsoy B; Turunc E; Guneri T; Yalcin A AAPS PharmSciTech 2009[]; 10 (1): 104-12 PMID19184450show ga In this study, we investigated the in vitro characteristics of mefenamic acid (MA) microparticles as well as their effects on DNA damage. MA-loaded chitosan and alginate beads were prepared by the ionotropic gelation process. Microsponges containing MA and Eudragit RS 100 were prepared by quasi-emulsion solvent diffusion method. The microparticles were characterized in terms of particle size, surface morphology, encapsulation efficiency, and in vitro release profiles. Most of the formulation variables manifested an influence on the physical characteristics of the microparticles at varying degrees. We also studied the effects of MA, MA-loaded microparticles, and three different polymers on rat brain cortex DNA damage. Our results showed that DNA damage was higher in MA-loaded Eudragit microsponges than MA-loaded biodegradable chitosan or alginate microparticles. |*DNA Damage[MESH] |Acrylic Resins/chemistry[MESH] |Alginates/chemistry[MESH] |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/chemistry/*pharmacology[MESH] |Cerebral Cortex/*drug effects/pathology[MESH] |Chemistry, Pharmaceutical[MESH] |Chitosan/chemistry[MESH] |Dosage Forms[MESH] |Drug Carriers[MESH] |Drug Compounding[MESH] |Excitatory Amino Acid Agonists/toxicity[MESH] |Glucuronic Acid/chemistry[MESH] |Hexuronic Acids/chemistry[MESH] |Kainic Acid/toxicity[MESH] |Kinetics[MESH] |Mefenamic Acid/chemistry/*pharmacology[MESH] |Neuroprotective Agents/chemistry/*pharmacology[MESH] |Particle Size[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Solubility[MESH]Studies on mefenamic acid microparticles: formulation, in vitro releas(epmc).pdf DeepDyve Pubget Overpricing