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10.4049/jimmunol.181.11.7936 http://scihub22266oqcxt.onion/10.4049/jimmunol.181.11.7936 19017984!ä!19017984 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2008 ; 181 (11): 7936-43 Nephropedia Template TP {{tp|p=19017984|t=2008. Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus |pdf=|usr=}}{{19017984}} gab.com Text Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=19017984 #FOAvip Surfactant protein D (SP-D) plays important roles in the initial innate defense against influenza A virus (IAV). The collagen domain of SP-D is probably critical for its homeostatic functions in vivo and has been implicated in the modulation of macrophage responses to SP-D-ligand complexes. For the current studies, we used a panel of rat SP-D mutants lacking all or part of the collagen domain to more specifically evaluate the contributions of this domain to viral interactions. SP-D multimers lacking the collagenous sequence efficiently neutralized Phil82 IAV, promoted neutrophil uptake of IAV, and also potentiated the IAV-induced neutrophil respiratory burst response. A dodecameric mutant with shortened collagenous arms showed enhanced viral aggregation and neuraminidase inhibition, and an increased capacity to inhibit a partially collectin-resistant strain of IAV. By contrast, truncated molecules lacking an N-terminal and collagen domain showed no detectable antiviral and opsonizing activity, despite preservation of lectin activity and detectable viral binding. Thus, multimerization, which is mediated by the N-peptide, is more important than the collagen domain for efficient viral neutralization and opsonization. However, the structure of the collagen domain significantly influences the anti-viral activity of multimerized forms of SP-D. Twit Text FOAVip Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=19017984 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19017984 #FOAvip English Wikipedia <ref>{{Cite pmid|19017984}}</ref> Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus #MMPMID19017984 White M; Kingma P; Tecle T; Kacak N; Linders B; Heuser J; Crouch E; Hartshorn K J Immunol 2008[Dec]; 181 (11): 7936-43 PMID19017984show ga Surfactant protein D (SP-D) plays important roles in the initial innate defense against influenza A virus (IAV). The collagen domain of SP-D is probably critical for its homeostatic functions in vivo and has been implicated in the modulation of macrophage responses to SP-D-ligand complexes. For the current studies, we used a panel of rat SP-D mutants lacking all or part of the collagen domain to more specifically evaluate the contributions of this domain to viral interactions. SP-D multimers lacking the collagenous sequence efficiently neutralized Phil82 IAV, promoted neutrophil uptake of IAV, and also potentiated the IAV-induced neutrophil respiratory burst response. A dodecameric mutant with shortened collagenous arms showed enhanced viral aggregation and neuraminidase inhibition, and an increased capacity to inhibit a partially collectin-resistant strain of IAV. By contrast, truncated molecules lacking an N-terminal and collagen domain showed no detectable antiviral and opsonizing activity, despite preservation of lectin activity and detectable viral binding. Thus, multimerization, which is mediated by the N-peptide, is more important than the collagen domain for efficient viral neutralization and opsonization. However, the structure of the collagen domain significantly influences the anti-viral activity of multimerized forms of SP-D. |*Immunity, Innate/genetics[MESH] |Animals[MESH] |Cell Line[MESH] |Dogs[MESH] |Homeostasis/genetics/immunology[MESH] |Humans[MESH] |Influenza A Virus, H3N2 Subtype/*immunology[MESH] |Influenza, Human/genetics/*immunology[MESH] |Ligands[MESH] |Macrophages/immunology[MESH] |Multiprotein Complexes/genetics/*immunology[MESH] |Mutation/immunology[MESH] |Neuraminidase/immunology[MESH] |Neutrophils/immunology[MESH] |Protein Structure, Tertiary/genetics[MESH] |Pulmonary Surfactant-Associated Protein D/genetics/*immunology[MESH] |Rats[MESH] |Respiratory Burst/genetics/immunology[MESH] |Structure-Activity Relationship[MESH]Multimerization of surfactant protein D, but not its collagen domain, (epmc).pdf DeepDyve Pubget Overpricing