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10.1007/s00424-008-0607-1 http://scihub22266oqcxt.onion/10.1007/s00424-008-0607-1 18982348!3584568!18982348     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pflugers+Arch 2009 ; 458 (1): 61-76 Nephropedia Template TP {{tp|p=18982348|t=2009. Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR |pdf=|usr=}}{{18982348}} gab.com Text Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR JO: Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=18982348 #FOAvip The thick ascending limb of Henle's loop is a nephron segment that is vital to the formation of dilute and concentrated urine. This ability is accomplished by a consortium of functionally coupled proteins consisting of the apical Na(+):K(+):2Cl(-) co-transporter, the K(+) channel, and basolateral Cl(-) channel that mediate electroneutral salt absorption. In thick ascending limbs, salt absorption is importantly regulated by the calcium-sensing receptor. Genetic or pharmacological disruption impairing the function of any of these proteins results in Bartter syndrome. The thick ascending limb is also an important site of Ca(2+) and Mg(2+) absorption. Calcium-sensing receptor activation inhibits cellular Ca(2+) absorption induced by parathyroid hormone, as well as passive paracellular Ca(2+) transport. The present review discusses these functions and their genetic and molecular regulation. Twit Text FOAVip Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR ????Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=18982348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18982348 #FOAvip English Wikipedia <ref>{{Cite pmid|18982348}}</ref> Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR #MMPMID18982348 Gamba G; Friedman PA Pflugers Arch 2009[May]; 458 (1): 61-76 PMID18982348show ga The thick ascending limb of Henle's loop is a nephron segment that is vital to the formation of dilute and concentrated urine. This ability is accomplished by a consortium of functionally coupled proteins consisting of the apical Na(+):K(+):2Cl(-) co-transporter, the K(+) channel, and basolateral Cl(-) channel that mediate electroneutral salt absorption. In thick ascending limbs, salt absorption is importantly regulated by the calcium-sensing receptor. Genetic or pharmacological disruption impairing the function of any of these proteins results in Bartter syndrome. The thick ascending limb is also an important site of Ca(2+) and Mg(2+) absorption. Calcium-sensing receptor activation inhibits cellular Ca(2+) absorption induced by parathyroid hormone, as well as passive paracellular Ca(2+) transport. The present review discusses these functions and their genetic and molecular regulation. |Alternative Splicing[MESH] |Amino Acid Sequence[MESH] |Bartter Syndrome/genetics[MESH] |Calcium/metabolism[MESH] |Cations, Divalent/metabolism[MESH] |GTP-Binding Proteins/physiology[MESH] |Hypertension/genetics[MESH] |Kinetics[MESH] |Loop of Henle/*metabolism[MESH] |Molecular Sequence Data[MESH] |Potassium Channels, Inwardly Rectifying/physiology[MESH] |Receptors, Calcium-Sensing/*physiology[MESH] |Signal Transduction/physiology[MESH] |Sodium-Potassium-Chloride Symporters/genetics/*metabolism/physiology[MESH]Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, a(epmc).pdf DeepDyve Pubget Overpricing