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10.4049/jimmunol.181.10.7367

http://scihub22266oqcxt.onion/10.4049/jimmunol.181.10.7367
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18981160!2607048!18981160
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suck abstract from ncbi


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pmid18981160      J+Immunol 2008 ; 181 (10): 7367-79
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  • Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice #MMPMID18981160
  • Menke J; Hsu MY; Byrne KT; Lucas JA; Rabacal WA; Croker BP; Zong XH; Stanley ER; Kelley VR
  • J Immunol 2008[Nov]; 181 (10): 7367-79 PMID18981160show ga
  • Sunlight (UVB) triggers cutaneous lupus erythematosus (CLE) and systemic lupus through an unknown mechanism. We tested the hypothesis that UVB triggers CLE through a CSF-1-dependent, macrophage (Mo)-mediated mechanism in MRL-Fas(lpr) mice. By constructing mutant MRL-Fas(lpr) strains expressing varying levels of CSF-1 (high, intermediate, none), and use of an ex vivo gene transfer to deliver CSF-1 intradermally, we determined that CSF-1 induces CLE in lupus-susceptible MRL-Fas(lpr) mice, but not in lupus-resistant BALB/c mice. UVB incites an increase in Mos, apoptosis in the skin, and CLE in MRL-Fas(lpr), but not in CSF-1-deficient MRL-Fas(lpr) mice. Furthermore, UVB did not induce CLE in BALB/c mice. Probing further, UVB stimulates CSF-1 expression by keratinocytes leading to recruitment and activation of Mos that, in turn, release mediators, which induce apoptosis in keratinocytes. Thus, sunlight triggers a CSF-1-dependent, Mo-mediated destructive inflammation in the skin leading to CLE in lupus-susceptible MRL-Fas(lpr) but not lupus-resistant BALB/c mice. Taken together, CSF-1 is envisioned as the match and lupus susceptibility as the tinder leading to CLE.
  • |Adoptive Transfer[MESH]
  • |Animals[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Fibroblasts/metabolism/pathology[MESH]
  • |Flow Cytometry[MESH]
  • |Fluorescent Antibody Technique[MESH]
  • |Gene Expression[MESH]
  • |Immunohistochemistry[MESH]
  • |Keratinocytes/metabolism/pathology[MESH]
  • |Lupus Erythematosus, Systemic/*etiology/immunology/*pathology[MESH]
  • |Macrophage Colony-Stimulating Factor/*genetics/metabolism[MESH]
  • |Macrophages/immunology/metabolism[MESH]
  • |Mice[MESH]
  • |Mice, Inbred MRL lpr[MESH]
  • |Mice, Transgenic[MESH]
  • |Skin Diseases/etiology/immunology/*pathology[MESH]


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