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10.1111/j.1369-1600.2008.00133.x http://scihub22266oqcxt.onion/10.1111/j.1369-1600.2008.00133.x 18855801/?report=reader!2758315!18855801     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18855801&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addict+Biol 2009 ; 14 (1): 73-83 Nephropedia Template TP {{tp|p=18855801|t=2009. Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin |pdf=|usr=}}{{18855801}} gab.com Text Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin JO: Addict Biol http://www.kidney.de/pget.php?&tw=1&pmid=18855801 #FOAvip There is a need for safe medications that can effectively support recovery by treating symptoms of protracted abstinence that may precipitate relapse in alcoholics, e.g. craving and disturbances in sleep and mood. This proof-of-concept study reports on the effectiveness of gabapentin 1200 mg for attenuating these symptoms in a non-treatment-seeking sample of cue-reactive, alcohol-dependent individuals. Subjects were 33 paid volunteers with current Diagnostic and Statistical Manual of Mental Disorders-IV alcohol dependence and a strength of craving rating 1 SD or greater for alcohol than water cues. Subjects were randomly assigned to gabapentin or placebo for 1 week and then participated in a within-subjects trial where each was exposed to standardized sets of pleasant, neutral and unpleasant visual stimuli followed by alcohol or water cues. Gabapentin was associated with significantly greater reductions than placebo on several measures of subjective craving for alcohol as well as for affectively evoked craving. Gabapentin was also associated with significant improvement on several measures of sleep quality. Side effects were minimal, and gabapentin effects were not found to resemble any major classes of abused drugs. Results suggest that gabapentin may be effective for treating the protracted abstinence phase in alcohol dependence and that a randomized clinical trial would be an appropriate next step. The study also suggests the value of cue-reactivity studies as proof-of-concept screens for potential antirelapse drugs. Twit Text FOAVip Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin ????Addict Biol http://www.kidney.de/pget.php?&tw=1&pmid=18855801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18855801 #FOAvip English Wikipedia <ref>{{Cite pmid|18855801}}</ref> Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin #MMPMID18855801 Mason BJ; Light JM; Williams LD; Drobes DJ Addict Biol 2009[Jan]; 14 (1): 73-83 PMID18855801show ga There is a need for safe medications that can effectively support recovery by treating symptoms of protracted abstinence that may precipitate relapse in alcoholics, e.g. craving and disturbances in sleep and mood. This proof-of-concept study reports on the effectiveness of gabapentin 1200 mg for attenuating these symptoms in a non-treatment-seeking sample of cue-reactive, alcohol-dependent individuals. Subjects were 33 paid volunteers with current Diagnostic and Statistical Manual of Mental Disorders-IV alcohol dependence and a strength of craving rating 1 SD or greater for alcohol than water cues. Subjects were randomly assigned to gabapentin or placebo for 1 week and then participated in a within-subjects trial where each was exposed to standardized sets of pleasant, neutral and unpleasant visual stimuli followed by alcohol or water cues. Gabapentin was associated with significantly greater reductions than placebo on several measures of subjective craving for alcohol as well as for affectively evoked craving. Gabapentin was also associated with significant improvement on several measures of sleep quality. Side effects were minimal, and gabapentin effects were not found to resemble any major classes of abused drugs. Results suggest that gabapentin may be effective for treating the protracted abstinence phase in alcohol dependence and that a randomized clinical trial would be an appropriate next step. The study also suggests the value of cue-reactivity studies as proof-of-concept screens for potential antirelapse drugs. |Adult[MESH] |Affect/drug effects[MESH] |Alcohol Deterrents/adverse effects/*therapeutic use[MESH] |Alcohol Withdrawal Delirium/psychology/*rehabilitation[MESH] |Alcoholism/psychology/*rehabilitation[MESH] |Amines/adverse effects/*therapeutic use[MESH] |Arousal/drug effects[MESH] |Cues[MESH] |Cyclohexanecarboxylic Acids/adverse effects/*therapeutic use[MESH] |Electromyography/drug effects[MESH] |Female[MESH] |Gabapentin[MESH] |Galvanic Skin Response/drug effects[MESH] |Heart Rate/drug effects[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Motivation[MESH] |Pain Measurement[MESH] |Secondary Prevention[MESH] |Sleep/drug effects[MESH] |Temperance/*psychology[MESH] |Treatment Outcome[MESH]Proof-of-concept human laboratory study for protracted abstinence in a(epmc).pdf DeepDyve Pubget Overpricing