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10.1681/ASN.2008020162 http://scihub22266oqcxt.onion/10.1681/ASN.2008020162 18832437!2573018!18832437     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2008 ; 19 (11): 2069-75 Nephropedia Template TP {{tp|p=18832437|t=2008. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury |pdf=|usr=}}{{18832437}} gab.com Text Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=18832437 #FOAvip MicroRNAs (miRNAs) are in a class of endogenous, small, noncoding RNAs that exert their effects through posttranscriptional repression of specific target mRNAs. Although miRNAs have been implicated in the regulation of diverse biologic processes, little is known about miRNA function in the kidney. Here, mice lacking functional miRNAs in the developing podocyte were generated through podocyte-specific knockout of Dicer, an enzyme required for the production of mature miRNAs (Nphs2-Cre; Dicer(flx/flx)). Podocyte-specific loss of miRNAs resulted in significant proteinuria by 2 wk after birth, rapid progression of marked glomerular and tubular injury beginning at 3 wk, and death by 4 wk. Expression of the slit diaphragm proteins nephrin and podocin was decreased, and expression of the transcription factor WT1 was relatively unaffected. To identify miRNA-mRNA interactions that contribute to this phenotype, we profiled the glomerular expression of miRNAs; three miRNAs expressed in glomeruli were identified: mmu-miR-23b, mmu-miR-24, and mmu-miR-26a. These results suggest that miRNA function is dispensable for the initial development of glomeruli but is critical to maintain the glomerular filtration barrier. Twit Text FOAVip Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=18832437 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18832437 #FOAvip English Wikipedia <ref>{{Cite pmid|18832437}}</ref> Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury #MMPMID18832437 Ho J; Ng KH; Rosen S; Dostal A; Gregory RI; Kreidberg JA J Am Soc Nephrol 2008[Nov]; 19 (11): 2069-75 PMID18832437show ga MicroRNAs (miRNAs) are in a class of endogenous, small, noncoding RNAs that exert their effects through posttranscriptional repression of specific target mRNAs. Although miRNAs have been implicated in the regulation of diverse biologic processes, little is known about miRNA function in the kidney. Here, mice lacking functional miRNAs in the developing podocyte were generated through podocyte-specific knockout of Dicer, an enzyme required for the production of mature miRNAs (Nphs2-Cre; Dicer(flx/flx)). Podocyte-specific loss of miRNAs resulted in significant proteinuria by 2 wk after birth, rapid progression of marked glomerular and tubular injury beginning at 3 wk, and death by 4 wk. Expression of the slit diaphragm proteins nephrin and podocin was decreased, and expression of the transcription factor WT1 was relatively unaffected. To identify miRNA-mRNA interactions that contribute to this phenotype, we profiled the glomerular expression of miRNAs; three miRNAs expressed in glomeruli were identified: mmu-miR-23b, mmu-miR-24, and mmu-miR-26a. These results suggest that miRNA function is dispensable for the initial development of glomeruli but is critical to maintain the glomerular filtration barrier. |Animals[MESH] |Base Sequence[MESH] |DEAD-box RNA Helicases/deficiency/genetics/metabolism[MESH] |DNA Primers/genetics[MESH] |Endoribonucleases/deficiency/genetics/metabolism[MESH] |Gene Expression[MESH] |Kidney Glomerulus/*injuries/*metabolism/pathology[MESH] |Kidney Tubules/*injuries/*metabolism/pathology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |MicroRNAs/*genetics/*metabolism[MESH] |Phenotype[MESH] |Podocytes/*metabolism/pathology[MESH]Podocyte-specific loss of functional microRNAs leads to rapid glomerul(epmc).pdf DeepDyve Pubget Overpricing