Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1084/jem.20080132 http://scihub22266oqcxt.onion/10.1084/jem.20080132 18809714!2556797!18809714     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18809714&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Exp+Med 2008 ; 205 (10): 2235-49 Nephropedia Template TP {{tp|p=18809714|t=2008. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein |pdf=|usr=}}{{18809714}} gab.com Text Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=18809714 #FOAvip Accumulation of myeloid-derived suppressor cells (MDSCs) associated with inhibition of dendritic cell (DC) differentiation is one of the major immunological abnormalities in cancer and leads to suppression of antitumor immune responses. The molecular mechanism of this phenomenon remains unclear. We report here that STAT3-inducible up-regulation of the myeloid-related protein S100A9 enhances MDSC production in cancer. Mice lacking this protein mounted potent antitumor immune responses and rejected implanted tumors. This effect was reversed by administration of wild-type MDSCs from tumor-bearing mice to S100A9-null mice. Overexpression of S100A9 in cultured embryonic stem cells or transgenic mice inhibited the differentiation of DCs and macrophages and induced accumulation of MDSCs. This study demonstrates that tumor-induced up-regulation of S100A9 protein is critically important for accumulation of MDSCs and reveals a novel molecular mechanism of immunological abnormalities in cancer. Twit Text FOAVip Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=18809714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18809714 #FOAvip English Wikipedia <ref>{{Cite pmid|18809714}}</ref> Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein #MMPMID18809714 Cheng P; Corzo CA; Luetteke N; Yu B; Nagaraj S; Bui MM; Ortiz M; Nacken W; Sorg C; Vogl T; Roth J; Gabrilovich DI J Exp Med 2008[Sep]; 205 (10): 2235-49 PMID18809714show ga Accumulation of myeloid-derived suppressor cells (MDSCs) associated with inhibition of dendritic cell (DC) differentiation is one of the major immunological abnormalities in cancer and leads to suppression of antitumor immune responses. The molecular mechanism of this phenomenon remains unclear. We report here that STAT3-inducible up-regulation of the myeloid-related protein S100A9 enhances MDSC production in cancer. Mice lacking this protein mounted potent antitumor immune responses and rejected implanted tumors. This effect was reversed by administration of wild-type MDSCs from tumor-bearing mice to S100A9-null mice. Overexpression of S100A9 in cultured embryonic stem cells or transgenic mice inhibited the differentiation of DCs and macrophages and induced accumulation of MDSCs. This study demonstrates that tumor-induced up-regulation of S100A9 protein is critically important for accumulation of MDSCs and reveals a novel molecular mechanism of immunological abnormalities in cancer. |Animals[MESH] |Bone Marrow Cells/cytology/physiology[MESH] |Calgranulin B/genetics/*metabolism[MESH] |Cell Differentiation/*physiology[MESH] |Dendritic Cells/cytology/*physiology[MESH] |Embryonic Stem Cells/cytology/physiology[MESH] |Female[MESH] |Hematopoietic Stem Cells/cytology/physiology[MESH] |Macrophages/cytology/physiology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Mice, Transgenic[MESH] |Myeloid Cells/cytology/*physiology[MESH] |NIH 3T3 Cells[MESH] |Neoplasms/*immunology/pathology[MESH] |Phenotype[MESH] |Reactive Oxygen Species/metabolism[MESH]Inhibition of dendritic cell differentiation and accumulation of myelo(epmc).pdf DeepDyve Pubget Overpricing