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10.1038/bjp.2008.342 http://scihub22266oqcxt.onion/10.1038/bjp.2008.342 18794892/?report=reader!2584924!18794892     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2008 ; 155 (5): 623-40 Nephropedia Template TP {{tp|p=18794892|t=2008. Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders |pdf=|usr=}}{{18794892}} gab.com Text Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=18794892 #FOAvip Injury to the CNS elicits a host defense reaction that utilizes astrocytes, microglia, neurons and oligodendrocytes. Neuroinflammation is a major host defense mechanism designed to restore normal structure and function after CNS insult, but like other forms of inflammation, chronic neuroinflammation may contribute to pathogenesis. The inducible haeme oxygenase isoform, haeme oxygenase-1 (HO-1), is a phase 2 enzyme upregulated in response to electrophilic xenobiotics, oxidative stress, cellular injury and disease. There is emerging evidence that HO-1 expression helps mediate the resolution of inflammation, including neuroinflammation. Whether this is solely because of the catabolism of haeme or includes additional mechanisms is unclear. This review provides a brief background on the molecular biology and biochemistry of haeme oxygenases and the actions of haeme, bilirubin, iron and carbon monoxide in the CNS. It then presents our current state of knowledge regarding HO-1 expression in the CNS, regulation of HO-1 induction in neural cells and discusses the prospect of pharmacological manipulation of HO-1 as therapy for CNS disorders. Because of recognized species and cellular differences in HO-1 regulation, a major objective of this review is to draw attention to areas where gaps exist in the experimental record regarding regulation of HO-1 in neural cells. The results indicate the HO-1 system to be an important therapeutic target in CNS disorders, but our understanding of HO-1 expression in human neural cells is severely lacking. Twit Text FOAVip Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=18794892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18794892 #FOAvip English Wikipedia <ref>{{Cite pmid|18794892}}</ref> Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders #MMPMID18794892 Syapin PJ Br J Pharmacol 2008[Nov]; 155 (5): 623-40 PMID18794892show ga Injury to the CNS elicits a host defense reaction that utilizes astrocytes, microglia, neurons and oligodendrocytes. Neuroinflammation is a major host defense mechanism designed to restore normal structure and function after CNS insult, but like other forms of inflammation, chronic neuroinflammation may contribute to pathogenesis. The inducible haeme oxygenase isoform, haeme oxygenase-1 (HO-1), is a phase 2 enzyme upregulated in response to electrophilic xenobiotics, oxidative stress, cellular injury and disease. There is emerging evidence that HO-1 expression helps mediate the resolution of inflammation, including neuroinflammation. Whether this is solely because of the catabolism of haeme or includes additional mechanisms is unclear. This review provides a brief background on the molecular biology and biochemistry of haeme oxygenases and the actions of haeme, bilirubin, iron and carbon monoxide in the CNS. It then presents our current state of knowledge regarding HO-1 expression in the CNS, regulation of HO-1 induction in neural cells and discusses the prospect of pharmacological manipulation of HO-1 as therapy for CNS disorders. Because of recognized species and cellular differences in HO-1 regulation, a major objective of this review is to draw attention to areas where gaps exist in the experimental record regarding regulation of HO-1 in neural cells. The results indicate the HO-1 system to be an important therapeutic target in CNS disorders, but our understanding of HO-1 expression in human neural cells is severely lacking. |*Heme Oxygenase-1/genetics/metabolism/physiology[MESH] |Animals[MESH] |Brain Diseases/drug therapy/*enzymology/immunology[MESH] |Brain/drug effects/enzymology/immunology[MESH] |Gene Expression Regulation, Enzymologic/drug effects[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation/drug therapy/*enzymology/immunology[MESH]Regulation of haeme oxygenase-1 for treatment of neuroinflammation and(epmc).pdf DeepDyve Pubget Overpricing