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10.1016/j.clim.2008.07.030 http://scihub22266oqcxt.onion/10.1016/j.clim.2008.07.030 18790673!ä!18790673 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2008 ; 129 (3): 471-81 Nephropedia Template TP {{tp|p=18790673|t=2008. B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer |pdf=|usr=}}{{18790673}} gab.com Text B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18790673 #FOAvip Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and are associated with immune suppression. Here, we described high level of expression of B7-H1 (CD274), PD-1 (CD279) and CTLA4 (CD152) by Gr-1(+)CD11b(+) MDSCs obtained from both ascites and spleens of mice bearing the 1D8 ovarian carcinoma, whereas B7-DC (CD273), CD40 and CD86 were absent. In contrast, B7-H1, PD-1 and CTLA-4 expression was not detected on Gr-1(+)CD11b(+) cells from naive mice. Expression of B7-H1 by Gr-1(+)CD11b(+) cells from naive mice could be induced by co-culture with 1D8 ovarian carcinoma cells. Gr-1(+)CD11b(+) cells derived from 1D8 tumor-bearing mice markedly suppressed antigen-specific immune responses, whereas Gr-1(+)CD11b(+) cells from naive mice did not. siRNA-mediated knockdown of B7-H1 in Gr-1(+)CD11b(+) cells of 1D8 tumor-bearing mice alleviated suppression of antigen-specific immune responses. Suppression of antigen-specific immune responses via B7-H1 on Gr-1(+)CD11b(+) myeloid cells was mediated by CD4(+)CD25(+) Foxp3(+) T regulatory cells and required PD-1. Antibody blockade of either B7-H1 or PD-1 retarded the growth of 1D8 tumor in mice. This suggests that expression of B7-H1 on Gr-1(+)CD11b(+) myeloid cells triggered by the 1D8 mouse model of ovarian carcinoma suppresses antigen-specific immunity via interaction with PD-1 on CD4(+)CD25(+) Foxp3(+) regulatory T cells. Twit Text FOAVip B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18790673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18790673 #FOAvip English Wikipedia <ref>{{Cite pmid|18790673}}</ref> B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer #MMPMID18790673 Liu Y; Zeng B; Zhang Z; Zhang Y; Yang R Clin Immunol 2008[Dec]; 129 (3): 471-81 PMID18790673show ga Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and are associated with immune suppression. Here, we described high level of expression of B7-H1 (CD274), PD-1 (CD279) and CTLA4 (CD152) by Gr-1(+)CD11b(+) MDSCs obtained from both ascites and spleens of mice bearing the 1D8 ovarian carcinoma, whereas B7-DC (CD273), CD40 and CD86 were absent. In contrast, B7-H1, PD-1 and CTLA-4 expression was not detected on Gr-1(+)CD11b(+) cells from naive mice. Expression of B7-H1 by Gr-1(+)CD11b(+) cells from naive mice could be induced by co-culture with 1D8 ovarian carcinoma cells. Gr-1(+)CD11b(+) cells derived from 1D8 tumor-bearing mice markedly suppressed antigen-specific immune responses, whereas Gr-1(+)CD11b(+) cells from naive mice did not. siRNA-mediated knockdown of B7-H1 in Gr-1(+)CD11b(+) cells of 1D8 tumor-bearing mice alleviated suppression of antigen-specific immune responses. Suppression of antigen-specific immune responses via B7-H1 on Gr-1(+)CD11b(+) myeloid cells was mediated by CD4(+)CD25(+) Foxp3(+) T regulatory cells and required PD-1. Antibody blockade of either B7-H1 or PD-1 retarded the growth of 1D8 tumor in mice. This suggests that expression of B7-H1 on Gr-1(+)CD11b(+) myeloid cells triggered by the 1D8 mouse model of ovarian carcinoma suppresses antigen-specific immunity via interaction with PD-1 on CD4(+)CD25(+) Foxp3(+) regulatory T cells. |Animals[MESH] |Antigens, CD/immunology[MESH] |Antigens, Differentiation/immunology/metabolism[MESH] |B7-1 Antigen/*biosynthesis/genetics/immunology[MESH] |B7-H1 Antigen[MESH] |CD11b Antigen/biosynthesis/immunology[MESH] |CTLA-4 Antigen[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Female[MESH] |Flow Cytometry[MESH] |Forkhead Transcription Factors/genetics/immunology[MESH] |Immunophenotyping[MESH] |Male[MESH] |Membrane Glycoproteins/*biosynthesis/genetics/immunology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Myeloid Cells/immunology[MESH] |Ovarian Neoplasms/genetics/*immunology/pathology[MESH] |Peptides/genetics/immunology[MESH] |Programmed Cell Death 1 Receptor[MESH] |RNA, Small Interfering/genetics[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |Signal Transduction[MESH] |Specific Pathogen-Free Organisms[MESH] |Spleen/immunology[MESH]B7-H1 on myeloid-derived suppressor cells in immune suppression by a m(epmc).pdf DeepDyve Pubget Overpricing