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  • Human Borna disease virus-infection and its therapy in affective disorders #MMPMID18771101
  • Dietrich DE; Bode L
  • APMIS Suppl 2008[]; ä (124): 61-5 PMID18771101garesp_yesshow ga
  • Patients with affective disorders show an enhanced prevalence of Borna disease virus (BDV)-infection. Furthermore, BDV causes latent infection preferably in limbic central nervous structures and is suggested to be causally related to subtypes of affective disorders, especially with melancholic clinical features or bipolarity. Such a possible link was highlighted by the first report of amantadine showing an antidepressive and an antiviral efficacy against BDV in a patient with a bipolar disorder. This article summarizes clinical studies which followed this first report on the use of amantadine in BDV-infected patients with an affective disorder. A special focus is given on an open clinical study in patients with depression (n = 25), a study in remitted patients with affective disorders (n = 16), and the effect of amantadine on severe hypomanic or moderately manic patients with a bipolar disorder in an on-off-on study. In these studies amantadine reduced clinical symptoms paralleled by a reduction of BDV-infection in depressive patients, it also reduced all three BDV-parameters (BDV-Ab, -AG, and -CICs) in remitted patients, and it even reduced severe hypomania and moderate mania in bipolar patients. These data suggest the existence of an etiopathogenetic link between BDV and subtypes of affective disorders.
  • |Amantadine/*therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Borna Disease/*drug therapy[MESH]
  • |Borna disease virus/*pathogenicity[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Depressive Disorder/drug therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Mood Disorders/*drug therapy/physiopathology[MESH]
  • |Virulence[MESH]


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  • garesp_yesshow ga

    61 124.ä 2008