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  • Borna disease virus: evidence of naturally-occurring infection in cats in Australia #MMPMID18771098
  • Kamhieh S; Hodgson JL; Bode L; Ludwig H; Flower RL
  • APMIS Suppl 2008[]; ä (124): 50-2 PMID18771098garesp_yesshow ga
  • In Europe, Borna disease virus (BDV) infection has been linked with staggering disease. The aim of this study was serological investigation for BDV infection in Australian cats. De-identified sera were obtained from domestic cats presented at various veterinary clinics. BDV antigen levels were measured by a monoclonal antibody-based ELISA. Antibody to BDV measured semiquantitatively by ELISA was detected in 0.8% of cats from South Australia and 3.2% of animals from NSW Confirmatory assays for ELISA positive samples included Western blot and immunofluorescence assay (IFA) with BDV-specific staining. Seven BDV-antigen positive sera (2.4%) were identified in sera from cats from New South Wales (NSW). In blinded testing, amongst a large number of negative results, repeat submissions over a seven-month period from a cat co-infected with Feline Immunodeficiency Virus (FIV) were BDV-antigen positive. Anti-BDV antibody detected in this cat by ELISA was confirmed by Western blot (p24/ p40/p56) and IFA. For 4 other anti-BDV ELISA-positive samples, specific reactions with BDV proteins were observed by Western blot. Ten other anti-BDV ELISA-positive samples were IFA positive. These data provide consistent serological evidence that, while horses in Australia are free of BDV infection, there may be a low rate of BDV infection in cats.
  • |Animals[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Antigens, Viral/blood[MESH]
  • |Australia/epidemiology[MESH]
  • |Blotting, Western[MESH]
  • |Borna Disease/blood/*epidemiology[MESH]
  • |Borna disease virus/*immunology[MESH]
  • |Cat Diseases/blood/*epidemiology[MESH]
  • |Cats[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Fluorescent Antibody Technique, Indirect[MESH]
  • |Seroepidemiologic Studies[MESH]


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  • garesp_yesshow ga

    50 124.ä 2008