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10.4049/jimmunol.181.6.3755 http://scihub22266oqcxt.onion/10.4049/jimmunol.181.6.3755 18768827!ä!18768827 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18768827&cmd=llinks): Failed to open stream: HTTP request failed! 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Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome |pdf=|usr=}}{{18768827}} gab.com Text Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18768827 #FOAvip Adjuvants are vaccine additives that stimulate the immune system without having any specific antigenic effect of itself. In this study we show that alum adjuvant induces the release of IL-1beta from macrophages and dendritic cells and that this is abrogated in cells lacking various NALP3 inflammasome components. The NALP3 inflammasome is also required in vivo for the innate immune response to OVA in alum. The early production of IL-1beta and the influx of inflammatory cells into the peritoneal cavity is strongly reduced in NALP3-deficient mice. The activation of adaptive cellular immunity to OVA-alum is initiated by monocytic dendritic cell precursors that induce the expansion of Ag-specific T cells in a NALP3-dependent way. We propose that, in addition to TLR stimulators, agonists of the NALP3 inflammasome should also be considered as vaccine adjuvants. Twit Text FOAVip Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18768827 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18768827 #FOAvip English Wikipedia <ref>{{Cite pmid|18768827}}</ref> Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome #MMPMID18768827 Kool M; Petrilli V; De Smedt T; Rolaz A; Hammad H; van Nimwegen M; Bergen IM; Castillo R; Lambrecht BN; Tschopp J J Immunol 2008[Sep]; 181 (6): 3755-9 PMID18768827show ga Adjuvants are vaccine additives that stimulate the immune system without having any specific antigenic effect of itself. In this study we show that alum adjuvant induces the release of IL-1beta from macrophages and dendritic cells and that this is abrogated in cells lacking various NALP3 inflammasome components. The NALP3 inflammasome is also required in vivo for the innate immune response to OVA in alum. The early production of IL-1beta and the influx of inflammatory cells into the peritoneal cavity is strongly reduced in NALP3-deficient mice. The activation of adaptive cellular immunity to OVA-alum is initiated by monocytic dendritic cell precursors that induce the expansion of Ag-specific T cells in a NALP3-dependent way. We propose that, in addition to TLR stimulators, agonists of the NALP3 inflammasome should also be considered as vaccine adjuvants. |Adjuvants, Immunologic/*pharmacology[MESH] |Alum Compounds/*pharmacology[MESH] |Aluminum Hydroxide/pharmacology[MESH] |Animals[MESH] |Carrier Proteins/biosynthesis/genetics/*physiology[MESH] |Dendritic Cells/*immunology/metabolism/*pathology[MESH] |Female[MESH] |Immunologic Factors/pharmacology[MESH] |Inflammation Mediators/*pharmacology[MESH] |Macrophage Activation/immunology[MESH] |Macrophages, Peritoneal/*immunology/metabolism/*pathology[MESH] |Magnesium Hydroxide/pharmacology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH]Cutting edge: alum adjuvant stimulates inflammatory dendritic cells th(epmc).pdf DeepDyve Pubget Overpricing