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10.1016/j.cmet.2008.07.005 http://scihub22266oqcxt.onion/10.1016/j.cmet.2008.07.005 18762024!ä!18762024 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2008 ; 8 (3): 237-48 Nephropedia Template TP {{tp|p=18762024|t=2008. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death |pdf=|usr=}}{{18762024}} gab.com Text Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=18762024 #FOAvip Oxidative stress in conjunction with glutathione depletion has been linked with various acute and chronic degenerative disorders, yet the molecular mechanisms have remained unclear. In contrast to the belief that oxygen radicals are detrimental to cells and tissues by unspecific oxidation of essential biomolecules, we now demonstrate that oxidative stress is sensed and transduced by glutathione peroxidase 4 (GPx4) into a-yet-unrecognized cell-death pathway. Inducible GPx4 inactivation in mice and cells revealed 12/15-lipoxygenase-derived lipid peroxidation as specific downstream event, triggering apoptosis-inducing factor (AIF)-mediated cell death. Cell death could be entirely prevented either by alpha-tocopherol (alpha-Toc), 12/15-lipoxygenase inhibitors, or siRNA-mediated AIF silencing. Accordingly, 12/15-lipoxygenase-deficient cells were highly resistant to glutathione depletion. Neuron-specific GPx4 depletion caused neurodegeneration in vivo and ex vivo, highlighting the importance of this pathway in neuronal cells. Since oxidative stress is common in the etiology of many human disorders, the identified pathway reveals promising targets for future therapies. Twit Text FOAVip Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=18762024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18762024 #FOAvip English Wikipedia <ref>{{Cite pmid|18762024}}</ref> Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death #MMPMID18762024 Seiler A; Schneider M; Forster H; Roth S; Wirth EK; Culmsee C; Plesnila N; Kremmer E; Radmark O; Wurst W; Bornkamm GW; Schweizer U; Conrad M Cell Metab 2008[Sep]; 8 (3): 237-48 PMID18762024show ga Oxidative stress in conjunction with glutathione depletion has been linked with various acute and chronic degenerative disorders, yet the molecular mechanisms have remained unclear. In contrast to the belief that oxygen radicals are detrimental to cells and tissues by unspecific oxidation of essential biomolecules, we now demonstrate that oxidative stress is sensed and transduced by glutathione peroxidase 4 (GPx4) into a-yet-unrecognized cell-death pathway. Inducible GPx4 inactivation in mice and cells revealed 12/15-lipoxygenase-derived lipid peroxidation as specific downstream event, triggering apoptosis-inducing factor (AIF)-mediated cell death. Cell death could be entirely prevented either by alpha-tocopherol (alpha-Toc), 12/15-lipoxygenase inhibitors, or siRNA-mediated AIF silencing. Accordingly, 12/15-lipoxygenase-deficient cells were highly resistant to glutathione depletion. Neuron-specific GPx4 depletion caused neurodegeneration in vivo and ex vivo, highlighting the importance of this pathway in neuronal cells. Since oxidative stress is common in the etiology of many human disorders, the identified pathway reveals promising targets for future therapies. |Alleles[MESH] |Animals[MESH] |Apoptosis Inducing Factor/antagonists & inhibitors/*metabolism[MESH] |Arachidonate 12-Lipoxygenase/deficiency/*metabolism[MESH] |Arachidonate 15-Lipoxygenase/deficiency/*metabolism[MESH] |Cell Death/drug effects/physiology[MESH] |Cells, Cultured[MESH] |Fluorenes/pharmacology[MESH] |Genotype[MESH] |Glutathione Peroxidase/deficiency/genetics/*metabolism[MESH] |Hippocampus/metabolism/pathology[MESH] |Humans[MESH] |Lipid Peroxidation/physiology[MESH] |Mice[MESH] |Mice, Congenic[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Neurons/metabolism/pathology[MESH] |Oxidative Stress/*physiology[MESH] |Phospholipid Hydroperoxide Glutathione Peroxidase[MESH] |RNA, Small Interfering/pharmacology[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH]Glutathione peroxidase 4 senses and translates oxidative stress into (epmc).pdf DeepDyve Pubget Overpricing