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10.1159/000151666

http://scihub22266oqcxt.onion/10.1159/000151666
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18753797!ä!18753797

suck abstract from ncbi


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pmid18753797      Kidney+Blood+Press+Res 2008 ; 31 (4): 280-9
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  • Role of serum- and glucocorticoid-inducible kinase SGK1 in glucocorticoid regulation of renal electrolyte excretion and blood pressure #MMPMID18753797
  • Boini KM; Nammi S; Grahammer F; Osswald H; Kuhl D; Lang F
  • Kidney Blood Press Res 2008[]; 31 (4): 280-9 PMID18753797show ga
  • BACKGROUND/AIMS: The serum- and glucocorticoid-inducible kinase SGK1 was originally cloned as a glucocorticoid-regulated gene and later as a transcriptional target for mineralocorticoids. SGK1 regulates channels and transporters including the renal Na(+) channel ENaC. It contributes to mineralocorticoid regulation of renal Na(+) excretion and salt appetite. The present study explored the contribution of SGK1 to effects of glucocorticoids on mineral and electrolyte metabolism. METHODS: SGK1-knockout mice (sgk1(-/-)) and their wild-type littermates (sgk1(+/+)) were analyzed in metabolic cages with or without treatment for 14 days with dexamethasone (3 mg/kg b.w., i.p.). Blood pressure was determined by the tail-cuff method. RESULTS: Prior to treatment fluid intake, urinary flow rate, urinary Na(+), K(+), phosphate and Cl(-) excretion, plasma electrolyte and glucose concentrations as well as blood pressure were similar in sgk1(-/-) and sgk1(+/+) mice. Dexamethasone did not significantly alter renal Na(+), K(+), Cl(-) and Ca(2+) excretion but decreased plasma Ca(2+) and phosphate concentration in sgk1(+/+) mice. The effect on Ca(2+) was significantly augmented and the effect on phosphate significantly blunted in sgk1(-/-) mice. Dexamethasone significantly increased fasting blood glucose concentrations in both genotypes. Dexamethasone increased blood pressure in sgk1(+/+) mice, an effect significantly blunted in sgk1(-/-) mice. CONCLUSIONS: The present observations disclose SGK1-sensitive glucocorticoid effects on calcium-phosphate metabolism and blood pressure.
  • |Animals[MESH]
  • |Blood Glucose/drug effects[MESH]
  • |Blood Pressure/*drug effects[MESH]
  • |Calcium/metabolism[MESH]
  • |Dexamethasone/pharmacology[MESH]
  • |Electrolytes/*metabolism[MESH]
  • |Glucocorticoids/*physiology[MESH]
  • |Immediate-Early Proteins/*physiology[MESH]
  • |Kidney/metabolism[MESH]
  • |Mice[MESH]
  • |Mice, Knockout[MESH]
  • |Phosphates/metabolism[MESH]


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