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10.1016/j.bbrc.2008.08.010 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2008.08.010 18703016!2570258!18703016     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2008 ; 375 (2): 225-9 Nephropedia Template TP {{tp|p=18703016|t=2008. WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane |pdf=|usr=}}{{18703016}} gab.com Text WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=18703016 #FOAvip TRPV5 and TRPV6 are two closely related epithelial calcium channels that mediate apical calcium entry in the transcellular calcium transport pathway. TRPV5, but not TRPV6, is enhanced by protein kinase WNK4 when expressed in Xenopus laevis oocytes. We report that the majority of human TRPV5 exogenously expressed in the Xenopus oocyte plasma membrane was complexly N-glycosylated whereas that for human TRPV6 was core-glycosylated. Unglycosylated N358Q mutants of TRPV5 and TRPV6 were able to be expressed in the plasma membrane albeit with decreased abilities in mediating calcium uptake. Syntaxin 6, a SNARE protein in the trans-Golgi network, blocked the complex glycosylation of TRPV5 and TRPV6, rendered the channels in core-glycosylated form. Blocking complex glycosylation of TRPV5 either by syntaxin 6 or by N358Q mutation abolished the enhancing effect of WNK4 on TRPV5. Thus the difference in membrane expression of TRPV5 and TRPV6 explains the selective effect of WNK4 on TRPV5, which is likely on the secretory pathway involving complex glycosylation of channel proteins. Twit Text FOAVip WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=18703016 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18703016 #FOAvip English Wikipedia <ref>{{Cite pmid|18703016}}</ref> WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane #MMPMID18703016 Jiang Y; Cong P; Williams SR; Zhang W; Na T; Ma HP; Peng JB Biochem Biophys Res Commun 2008[Oct]; 375 (2): 225-9 PMID18703016show ga TRPV5 and TRPV6 are two closely related epithelial calcium channels that mediate apical calcium entry in the transcellular calcium transport pathway. TRPV5, but not TRPV6, is enhanced by protein kinase WNK4 when expressed in Xenopus laevis oocytes. We report that the majority of human TRPV5 exogenously expressed in the Xenopus oocyte plasma membrane was complexly N-glycosylated whereas that for human TRPV6 was core-glycosylated. Unglycosylated N358Q mutants of TRPV5 and TRPV6 were able to be expressed in the plasma membrane albeit with decreased abilities in mediating calcium uptake. Syntaxin 6, a SNARE protein in the trans-Golgi network, blocked the complex glycosylation of TRPV5 and TRPV6, rendered the channels in core-glycosylated form. Blocking complex glycosylation of TRPV5 either by syntaxin 6 or by N358Q mutation abolished the enhancing effect of WNK4 on TRPV5. Thus the difference in membrane expression of TRPV5 and TRPV6 explains the selective effect of WNK4 on TRPV5, which is likely on the secretory pathway involving complex glycosylation of channel proteins. |Amino Acid Substitution[MESH] |Animals[MESH] |Blood Proteins/*metabolism[MESH] |Calcium Channels/genetics/metabolism[MESH] |Glycosylation[MESH] |Humans[MESH] |Mutation[MESH] |Oocytes[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH] |Qa-SNARE Proteins/genetics/metabolism[MESH] |TRPV Cation Channels/genetics/*metabolism[MESH]WNK4 regulates the secretory pathway via which TRPV5 is targeted to th(epmc).pdf DeepDyve Pubget Overpricing