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10.1038/ni.1637 http://scihub22266oqcxt.onion/10.1038/ni.1637 18660812!ä!18660812 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2008 ; 9 (9): 1074-83 Nephropedia Template TP {{tp|p=18660812|t=2008. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection |pdf=|usr=}}{{18660812}} gab.com Text A critical function for CD200 in lung immune homeostasis and the severity of influenza infection JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18660812 #FOAvip The lung must maintain a high threshold of immune 'ignorance' to innocuous antigens to avoid inflammatory disease that depends on the balance of positive inflammatory signals and repressor pathways. We demonstrate here that airway macrophages had higher expression of the negative regulator CD200 receptor (CD200R) than did their systemic counterparts. Lung macrophages were restrained by CD200 expressed on airway epithelium. Mice lacking CD200 had more macrophage activity and enhanced sensitivity to influenza infection, which led to delayed resolution of inflammation and, ultimately, death. The administration of agonists that bind CD200R, however, prevented inflammatory lung disease. Thus, CD200R is critical for lung macrophage immune homeostasis in the resting state and limits inflammatory amplitude and duration during pulmonary influenza infection. Twit Text FOAVip A critical function for CD200 in lung immune homeostasis and the severity of influenza infection ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18660812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18660812 #FOAvip English Wikipedia <ref>{{Cite pmid|18660812}}</ref> A critical function for CD200 in lung immune homeostasis and the severity of influenza infection #MMPMID18660812 Snelgrove RJ; Goulding J; Didierlaurent AM; Lyonga D; Vekaria S; Edwards L; Gwyer E; Sedgwick JD; Barclay AN; Hussell T Nat Immunol 2008[Sep]; 9 (9): 1074-83 PMID18660812show ga The lung must maintain a high threshold of immune 'ignorance' to innocuous antigens to avoid inflammatory disease that depends on the balance of positive inflammatory signals and repressor pathways. We demonstrate here that airway macrophages had higher expression of the negative regulator CD200 receptor (CD200R) than did their systemic counterparts. Lung macrophages were restrained by CD200 expressed on airway epithelium. Mice lacking CD200 had more macrophage activity and enhanced sensitivity to influenza infection, which led to delayed resolution of inflammation and, ultimately, death. The administration of agonists that bind CD200R, however, prevented inflammatory lung disease. Thus, CD200R is critical for lung macrophage immune homeostasis in the resting state and limits inflammatory amplitude and duration during pulmonary influenza infection. |Animals[MESH] |Antigens, CD/*immunology[MESH] |Cytokines/biosynthesis[MESH] |Homeostasis/immunology/*physiology[MESH] |Humans[MESH] |Influenza, Human/*immunology/pathology[MESH] |Lung/*immunology/metabolism[MESH] |Mice[MESH]A critical function for CD200 in lung immune homeostasis and the sever(epmc).pdf DeepDyve Pubget Overpricing