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10.1038/ki.2008.322 http://scihub22266oqcxt.onion/10.1038/ki.2008.322 18633347!2909845!18633347     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2008 ; 74 (8): 1004-8 Nephropedia Template TP {{tp|p=18633347|t=2008. WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny |pdf=|usr=}}{{18633347}} gab.com Text WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=18633347 #FOAvip WNT signaling is a fundamental molecular pathway in both embryogenesis and disease. Nephron development is dependent on WNT signaling. The nephron epithelia proximal to the collecting duct develop from progenitor cells in the metanephric mesenchyme. The process involves formation of proto-epithelial cell aggregates, conversion into epithelia, and proximal-distal patterning of the nephron. Two ligands from the WNT family, namely Wnt9b and Wnt4, are required for nephron differentiation. Recent studies have addressed the downstream targets of these WNT ligands and delineated the role of the canonical WNT signaling pathway. This pathway depends on the intracellular protein beta-catenin and the T cell-specific transcription factor/lymphoid enhancer factor-1 (TCF/Lef1) family of transcription factors. Selective beta-catenin signaling antagonism inhibits differentiation of metanephric mesenchymal progenitor cells, while forced activation triggers a stage progression towards proto-epithelial aggregates. Nonetheless, activation of the pathway is transient during epithelial differentiation and titration of pathway activity may be central for the proper coordination of differentiation and morphogenesis. We review current evidence on the WNT/beta-catenin/TCF/Lef1 signaling pathway in kidney epithelial development and discuss the potential implication of non-canonical WNT signaling and WNT-independent events. Twit Text FOAVip WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=18633347 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18633347 #FOAvip English Wikipedia <ref>{{Cite pmid|18633347}}</ref> WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny #MMPMID18633347 Schmidt-Ott KM; Barasch J Kidney Int 2008[Oct]; 74 (8): 1004-8 PMID18633347show ga WNT signaling is a fundamental molecular pathway in both embryogenesis and disease. Nephron development is dependent on WNT signaling. The nephron epithelia proximal to the collecting duct develop from progenitor cells in the metanephric mesenchyme. The process involves formation of proto-epithelial cell aggregates, conversion into epithelia, and proximal-distal patterning of the nephron. Two ligands from the WNT family, namely Wnt9b and Wnt4, are required for nephron differentiation. Recent studies have addressed the downstream targets of these WNT ligands and delineated the role of the canonical WNT signaling pathway. This pathway depends on the intracellular protein beta-catenin and the T cell-specific transcription factor/lymphoid enhancer factor-1 (TCF/Lef1) family of transcription factors. Selective beta-catenin signaling antagonism inhibits differentiation of metanephric mesenchymal progenitor cells, while forced activation triggers a stage progression towards proto-epithelial aggregates. Nonetheless, activation of the pathway is transient during epithelial differentiation and titration of pathway activity may be central for the proper coordination of differentiation and morphogenesis. We review current evidence on the WNT/beta-catenin/TCF/Lef1 signaling pathway in kidney epithelial development and discuss the potential implication of non-canonical WNT signaling and WNT-independent events. |Animals[MESH] |Epithelial Cells/cytology[MESH] |Humans[MESH] |Kidney/cytology/*embryology/growth & development[MESH] |Nephrons/cytology/embryology[MESH] |Organogenesis[MESH] |Stem Cells/cytology[MESH] |TCF Transcription Factors[MESH] |Wnt Proteins/*metabolism[MESH]WNT/beta-catenin signaling in nephron progenitors and their epithelial(epmc).pdf DeepDyve Pubget Overpricing