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10.1016/j.bmcl.2008.05.042 http://scihub22266oqcxt.onion/10.1016/j.bmcl.2008.05.042 18538567!?!18538567       Bioorg+Med+Chem+Lett 2008 ; 18 (13): 3737-40 Nephropedia Template TP {{tp|p=18538567|t=2008. Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline |pdf=|usr=}}{{18538567}} gab.com Text Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline JO: Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=18538567 #FOAvip Two pyrrolizidinylalkyl derivatives of 4-amino-7-chloroquinoline (MG2 and MG3) were prepared and tested in vitro against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and in vivo in a Plasmodium berghei mouse model of infection. Both compounds exhibited excellent activity in all tests and low toxicity against mammalian cells. Preliminary studies of the acute toxicity and of the metabolism of the most active compound MG3 indicate a promising profile as a new antimalarial drug candidate. Twit Text FOAVip Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline ????Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=18538567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18538567 #FOAvip English Wikipedia <ref>{{Cite pmid|18538567}}</ref> Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline #MMPMID18538567 Sparatore A; Basilico N; Casagrande M; Parapini S; Taramelli D; Brun R; Wittlin S; Sparatore F Bioorg Med Chem Lett 2008[Jul]; 18 (13): 3737-40 PMID18538567show ga Two pyrrolizidinylalkyl derivatives of 4-amino-7-chloroquinoline (MG2 and MG3) were prepared and tested in vitro against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and in vivo in a Plasmodium berghei mouse model of infection. Both compounds exhibited excellent activity in all tests and low toxicity against mammalian cells. Preliminary studies of the acute toxicity and of the metabolism of the most active compound MG3 indicate a promising profile as a new antimalarial drug candidate. |Aminoquinolines/*chemical synthesis/chemistry[MESH] |Animals[MESH] |Antimalarials/*pharmacology[MESH] |Body Weight[MESH] |Cell Line[MESH] |Chloroquine/chemistry[MESH] |Humans[MESH] |Malaria/*drug therapy[MESH] |Mice[MESH] |Microsomes/drug effects[MESH] |Models, Chemical[MESH] |Plasmodium berghei/metabolism[MESH] |Plasmodium falciparum/metabolism[MESH]Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoqu(epmc).pdf DeepDyve Pubget Overpricing