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10.1186/1744-8069-4-22 http://scihub22266oqcxt.onion/10.1186/1744-8069-4-22 18534015!2430548!18534015     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18534015&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Mol+Pain 2008 ; 4 (?): 22 Nephropedia Template TP {{tp|p=18534015|t=2008. TRPM8 mechanism of autonomic nerve response to cold in respiratory airway |pdf=|usr=}}{{18534015}} gab.com Text TRPM8 mechanism of autonomic nerve response to cold in respiratory airway JO: Mol Pain http://www.kidney.de/pget.php?&tw=1&pmid=18534015 #FOAvip Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involved in the cold-induced respiratory responses through autonomic nerve reflex. However, molecular mechanisms by which vagal afferent fibers are excited by cold remain unknown. Using retrograde labeling, immunostaining, calcium imaging, and electrophysiological recordings, here we show that a subpopulation of airway vagal afferent nerves express TRPM8 receptors and that activation of TRPM8 receptors by cold excites these airway autonomic nerves. Thus activation of TRPM8 receptors may provoke autonomic nerve reflex to increase airway resistance. This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders. Twit Text FOAVip TRPM8 mechanism of autonomic nerve response to cold in respiratory airway ????Mol Pain http://www.kidney.de/pget.php?&tw=1&pmid=18534015 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18534015 #FOAvip English Wikipedia <ref>{{Cite pmid|18534015}}</ref> TRPM8 mechanism of autonomic nerve response to cold in respiratory airway #MMPMID18534015 Xing H; Ling JX; Chen M; Johnson RD; Tominaga M; Wang CY; Gu J Mol Pain 2008[Jun]; 4 (?): 22 PMID18534015show ga Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involved in the cold-induced respiratory responses through autonomic nerve reflex. However, molecular mechanisms by which vagal afferent fibers are excited by cold remain unknown. Using retrograde labeling, immunostaining, calcium imaging, and electrophysiological recordings, here we show that a subpopulation of airway vagal afferent nerves express TRPM8 receptors and that activation of TRPM8 receptors by cold excites these airway autonomic nerves. Thus activation of TRPM8 receptors may provoke autonomic nerve reflex to increase airway resistance. This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders. |*Cold Temperature[MESH] |Afferent Pathways/physiology[MESH] |Airway Resistance/physiology[MESH] |Animals[MESH] |Autonomic Pathways/*physiology[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Respiratory System/*innervation[MESH] |TRPM Cation Channels/*physiology[MESH]TRPM8 mechanism of autonomic nerve response to cold in respiratory air(epmc).pdf DeepDyve Pubget Overpricing