Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1515/dmdi.2008.23.1-2.93 http://scihub22266oqcxt.onion/10.1515/dmdi.2008.23.1-2.93 18533366!ä!18533366 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Metabol+Drug+Interact 2008 ; 23 (1-2): 93-124 Nephropedia Template TP {{tp|p=18533366|t=2008. Methylglyoxal, diabetes mellitus and diabetic complications |pdf=|usr=}}{{18533366}} gab.com Text Methylglyoxal, diabetes mellitus and diabetic complications JO: Drug Metabol Drug Interact http://www.kidney.de/pget.php?&tw=1&pmid=18533366 #FOAvip A large literature has developed around methylglyoxal (MG) concerning its role in diabetes mellitus (DM) and in the development of diabetic complications. This is related to the observation that levels of reactive aldehydes, especially 2-oxoaldehydes such as MG, are elevated in DM. There are numerous metabolic origins of MG that are accentuated in DM. MG has effects on insulin secretion from pancreatic beta-cells and is a major precursor of advanced glycation endproducts (AGE). Consequently, MG has a role in primary DM as well in the etiology of long-term complications. There is an extensive literature concerning the enzymes involved in the metabolism of MG, especially the glyoxalase system and aldose reductase. In addition, there is a rapidly developing literature on the direct and indirect effects of MG on signaling pathways that impact DM. This review attempts to integrate this DM-associated literature related to MG. Twit Text FOAVip Methylglyoxal, diabetes mellitus and diabetic complications ????Drug Metabol Drug Interact http://www.kidney.de/pget.php?&tw=1&pmid=18533366 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18533366 #FOAvip English Wikipedia <ref>{{Cite pmid|18533366}}</ref> Methylglyoxal, diabetes mellitus and diabetic complications #MMPMID18533366 Vander Jagt DL Drug Metabol Drug Interact 2008[]; 23 (1-2): 93-124 PMID18533366show ga A large literature has developed around methylglyoxal (MG) concerning its role in diabetes mellitus (DM) and in the development of diabetic complications. This is related to the observation that levels of reactive aldehydes, especially 2-oxoaldehydes such as MG, are elevated in DM. There are numerous metabolic origins of MG that are accentuated in DM. MG has effects on insulin secretion from pancreatic beta-cells and is a major precursor of advanced glycation endproducts (AGE). Consequently, MG has a role in primary DM as well in the etiology of long-term complications. There is an extensive literature concerning the enzymes involved in the metabolism of MG, especially the glyoxalase system and aldose reductase. In addition, there is a rapidly developing literature on the direct and indirect effects of MG on signaling pathways that impact DM. This review attempts to integrate this DM-associated literature related to MG. |Aldehydes/metabolism[MESH] |Diabetes Complications/metabolism[MESH] |Diabetes Mellitus/*metabolism[MESH] |Glycation End Products, Advanced/metabolism[MESH] |Humans[MESH] |Insulin/physiology[MESH] |Oxidative Stress/physiology[MESH] |Pyruvaldehyde/*metabolism[MESH]Methylglyoxal, diabetes mellitus and diabetic complications (epmc).pdf DeepDyve Pubget Overpricing