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10.1016/j.amjcard.2008.03.002 http://scihub22266oqcxt.onion/10.1016/j.amjcard.2008.03.002 18514628!ä!18514628 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Cardiol 2008 ; 101 (11A): 57E-62E Nephropedia Template TP {{tp|p=18514628|t=2008. Amino acid supplements improve native antioxidant enzyme expression in the skeletal muscle of diabetic mice |pdf=|usr=}}{{18514628}} gab.com Text Amino acid supplements improve native antioxidant enzyme expression in the skeletal muscle of diabetic mice JO: Am J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=18514628 #FOAvip Oxidative stress plays an important role in the pathogenesis of diabetic complications. We investigated the effects of a specific oral mixture of amino acid (AA) supplements on the antioxidant defense system, superoxide dismutase (SOD), and heat shock proteins (HSPs: HspB1, similar to Hsp 20 kDa, and HspB7) in the soleus muscle of streptozotocin (STZ)-diabetic mice by bidimensional electrophoresis and mass spectrometry. Four groups of 5 mice were considered: nondiabetic control mice, nondiabetic mice given AA supplements (0.1 g/kg per day for 15 days), diabetic mice (induced with STZ 65 mg/kg), and diabetic mice given AAs. AA supplements in the nondiabetic animals were associated with a statistical increase of SOD and no changes in expression of HSPs. Diabetes mellitus decreased antioxidant SOD and increased cellular stress as demonstrated by the overall upregulated HSPs. Administration of AAs counteracted the effects of diabetes, producing upregulation of SOD and downregulation of HSPs. These data suggest a role for AA supplements in controlling the antioxidant defense system and reducing the oxidative stress in diabetic skeletal muscle. Twit Text FOAVip Amino acid supplements improve native antioxidant enzyme expression in the skeletal muscle of diabetic mice ????Am J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=18514628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18514628 #FOAvip English Wikipedia <ref>{{Cite pmid|18514628}}</ref> Amino acid supplements improve native antioxidant enzyme expression in the skeletal muscle of diabetic mice #MMPMID18514628 Brocca L; D'Antona G; Bachi A; Pellegrino MA Am J Cardiol 2008[Jun]; 101 (11A): 57E-62E PMID18514628show ga Oxidative stress plays an important role in the pathogenesis of diabetic complications. We investigated the effects of a specific oral mixture of amino acid (AA) supplements on the antioxidant defense system, superoxide dismutase (SOD), and heat shock proteins (HSPs: HspB1, similar to Hsp 20 kDa, and HspB7) in the soleus muscle of streptozotocin (STZ)-diabetic mice by bidimensional electrophoresis and mass spectrometry. Four groups of 5 mice were considered: nondiabetic control mice, nondiabetic mice given AA supplements (0.1 g/kg per day for 15 days), diabetic mice (induced with STZ 65 mg/kg), and diabetic mice given AAs. AA supplements in the nondiabetic animals were associated with a statistical increase of SOD and no changes in expression of HSPs. Diabetes mellitus decreased antioxidant SOD and increased cellular stress as demonstrated by the overall upregulated HSPs. Administration of AAs counteracted the effects of diabetes, producing upregulation of SOD and downregulation of HSPs. These data suggest a role for AA supplements in controlling the antioxidant defense system and reducing the oxidative stress in diabetic skeletal muscle. |*Dietary Supplements[MESH] |Amino Acids/*administration & dosage[MESH] |Animals[MESH] |Diabetes Mellitus, Experimental/*enzymology/physiopathology[MESH] |Electrophoresis[MESH] |Heat-Shock Proteins/metabolism[MESH] |Hyperglycemia/enzymology/physiopathology[MESH] |Male[MESH] |Mass Spectrometry[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Muscle, Skeletal/drug effects/*enzymology[MESH] |Oxidative Stress/drug effects/physiology[MESH]Amino acid supplements improve native antioxidant enzyme expression in(epmc).pdf DeepDyve Pubget Overpricing