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10.1016/j.amjcard.2008.03.001 http://scihub22266oqcxt.onion/10.1016/j.amjcard.2008.03.001 18514627!ä!18514627 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Cardiol 2008 ; 101 (11A): 49E-56E Nephropedia Template TP {{tp|p=18514627|t=2008. Amino acid supplementation counteracts metabolic and functional damage in the diabetic rat heart |pdf=|usr=}}{{18514627}} gab.com Text Amino acid supplementation counteracts metabolic and functional damage in the diabetic rat heart JO: Am J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=18514627 #FOAvip We aimed to assess whether a specific mixture of amino acid (AA) supplements counteracts the metabolic and functional changes in the streptozotocin (STZ)-induced diabetic rat heart model. Adult male Wistar rats were divided into 6 groups (n = 10 each) and treated for 43 days: nondiabetic controls, nondiabetic rats given an AA mixture (0.1 g/kg per day), diabetic rats (induced with 65 mg/kg STZ given intraperitoneally), diabetic rats given AAs, diabetic rats given insulin (5 IU/day given subcutaneously), and diabetic rats given insulin plus AAs. During treatment, glycemia and insulinemia levels were measured in all groups. Changes in enzyme (reduced nicotinamide adenine dinucleotide-dehydrogenase, cytochrome c oxidase) activities and myosin heavy chain (MHC) composition were measured in the left ventricle. In 5 rats contractile function was assessed by measuring maximal shortening velocity of skinned ventricular trabeculae and the expression of translational regulator mammalian target of rapamycin (mTOR) was also found. STZ-induced diabetes was associated with reduced myocardial contractility, overall loss of oxidative capacity, a shift toward a slower MHC phenotype, and decreased mTOR tissue content. All of these changes appeared to be reversible with insulin. AA supplements partially restored the myocardial and oxidative dysfunction and also increased mTOR tissue content. The combination of insulin and AAs did not have a synergistic effect on either enzymatic or functional profiles. We conclude that AA supplements may contribute to restoring the oxidative and contractile dysfunction of diabetic rat hearts, probably through an mTOR-insulin independent mechanism. Twit Text FOAVip Amino acid supplementation counteracts metabolic and functional damage in the diabetic rat heart ????Am J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=18514627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18514627 #FOAvip English Wikipedia <ref>{{Cite pmid|18514627}}</ref> Amino acid supplementation counteracts metabolic and functional damage in the diabetic rat heart #MMPMID18514627 Pellegrino MA; Patrini C; Pasini E; Brocca L; Flati V; Corsetti G; D'Antona G Am J Cardiol 2008[Jun]; 101 (11A): 49E-56E PMID18514627show ga We aimed to assess whether a specific mixture of amino acid (AA) supplements counteracts the metabolic and functional changes in the streptozotocin (STZ)-induced diabetic rat heart model. Adult male Wistar rats were divided into 6 groups (n = 10 each) and treated for 43 days: nondiabetic controls, nondiabetic rats given an AA mixture (0.1 g/kg per day), diabetic rats (induced with 65 mg/kg STZ given intraperitoneally), diabetic rats given AAs, diabetic rats given insulin (5 IU/day given subcutaneously), and diabetic rats given insulin plus AAs. During treatment, glycemia and insulinemia levels were measured in all groups. Changes in enzyme (reduced nicotinamide adenine dinucleotide-dehydrogenase, cytochrome c oxidase) activities and myosin heavy chain (MHC) composition were measured in the left ventricle. In 5 rats contractile function was assessed by measuring maximal shortening velocity of skinned ventricular trabeculae and the expression of translational regulator mammalian target of rapamycin (mTOR) was also found. STZ-induced diabetes was associated with reduced myocardial contractility, overall loss of oxidative capacity, a shift toward a slower MHC phenotype, and decreased mTOR tissue content. All of these changes appeared to be reversible with insulin. AA supplements partially restored the myocardial and oxidative dysfunction and also increased mTOR tissue content. The combination of insulin and AAs did not have a synergistic effect on either enzymatic or functional profiles. We conclude that AA supplements may contribute to restoring the oxidative and contractile dysfunction of diabetic rat hearts, probably through an mTOR-insulin independent mechanism. |*Dietary Supplements[MESH] |Amino Acids/*administration & dosage[MESH] |Animals[MESH] |Blotting, Western[MESH] |Carrier Proteins/metabolism[MESH] |Diabetes Mellitus, Experimental/metabolism/*physiopathology[MESH] |Electron Transport Complex IV/metabolism[MESH] |Heart/*drug effects[MESH] |Intracellular Signaling Peptides and Proteins[MESH] |Male[MESH] |Myocardium/*metabolism[MESH] |Phosphoproteins/metabolism[MESH] |Phosphorylation[MESH] |Protein Kinases/metabolism[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Ribosomal Protein S6 Kinases/metabolism[MESH] |Signal Transduction/physiology[MESH] |TOR Serine-Threonine Kinases[MESH]Amino acid supplementation counteracts metabolic and functional damage(epmc).pdf DeepDyve Pubget Overpricing