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10.1016/j.bbalip.2008.04.001 http://scihub22266oqcxt.onion/10.1016/j.bbalip.2008.04.001 18455518!2577601!18455518     free     free     free       Biochim+Biophys+Acta 2008 ; 1781 (9): 582-7 Nephropedia Template TP {{tp|p=18455518|t=2008. Lysophosphatidic acid and renal fibrosis |pdf=|usr=}}{{18455518}} gab.com Text Lysophosphatidic acid and renal fibrosis JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=18455518 #FOAvip The development of fibrosis involves a multitude of events and molecules. Until now the majority of these molecules were found to be proteins or peptides. But recent data show significant involvement of the phospholipid lysophosphatidic acid (LPA) in the development of pulmonary, liver and renal fibrosis. The latest data on the role of LPA and the G-protein-coupled LPA1 receptor in the development of renal fibrosis will be discussed. LPA1-receptor activation was found to be associated with increased vascular leakage and increased fibroblast recruitment in pulmonary fibrosis. Furthermore, in renal fibrosis LPA1-receptor activation stimulates macrophage recruitment and connective tissue growth factor expression. The observations make this receptor an interesting alternative and new therapeutic target in fibrotic diseases. Twit Text FOAVip Lysophosphatidic acid and renal fibrosis ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=18455518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18455518 #FOAvip English Wikipedia <ref>{{Cite pmid|18455518}}</ref> Lysophosphatidic acid and renal fibrosis #MMPMID18455518 Pradere JP; Gonzalez J; Klein J; Valet P; Gres S; Salant D; Bascands JL; Saulnier-Blache JS; Schanstra JP Biochim Biophys Acta 2008[Sep]; 1781 (9): 582-7 PMID18455518show ga The development of fibrosis involves a multitude of events and molecules. Until now the majority of these molecules were found to be proteins or peptides. But recent data show significant involvement of the phospholipid lysophosphatidic acid (LPA) in the development of pulmonary, liver and renal fibrosis. The latest data on the role of LPA and the G-protein-coupled LPA1 receptor in the development of renal fibrosis will be discussed. LPA1-receptor activation was found to be associated with increased vascular leakage and increased fibroblast recruitment in pulmonary fibrosis. Furthermore, in renal fibrosis LPA1-receptor activation stimulates macrophage recruitment and connective tissue growth factor expression. The observations make this receptor an interesting alternative and new therapeutic target in fibrotic diseases. |Animals[MESH] |Fibrosis/metabolism[MESH] |Humans[MESH] |Kidney Diseases/*metabolism/physiopathology[MESH] |Lysophospholipids/*metabolism[MESH] |Models, Biological[MESH]Lysophosphatidic acid and renal fibrosis (epmc).pdf DeepDyve Pubget Overpricing