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10.1093/ndt/gfn215 http://scihub22266oqcxt.onion/10.1093/ndt/gfn215 18443212!2720810!18443212     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18443212&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nephrol+Dial+Transplant 2008 ; 23 (10): 3184-91 Nephropedia Template TP {{tp|p=18443212|t=2008. A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS |pdf=|usr=}}{{18443212}} gab.com Text A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS JO: Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=18443212 #FOAvip BACKGROUND: Chronic kidney disease (CKD) phenotypes such as albuminuria measured by urinary albumin creatinine ratio (ACR), elevated serum creatinine (SrCr) and/or decreased creatinine clearance (CrCl) and glomerular filtration rate (eGFR) are major risk factors for renal and cardiovascular diseases. Epidemiological studies have reported that CKD phenotypes cluster in families suggesting a genetic predisposition. However, studies reporting chromosomal regions influencing CKD are very limited. Therefore, the purpose of this study is to identify susceptible chromosomal regions for CKD phenotypes in Mexican American families enrolled in the San Antonio Family Heart Study (SAFHS). METHODS: We used the variance components decomposition approach (implemented in the software package SOLAR) to perform linkage analysis on 848 participants from 26 families. A total of 417 microsatellite markers were genotyped at an average interval of 10 cM spanning 22 autosomal chromosomes. RESULTS: All phenotypes were measured by standard procedures. Mean +/- SD values of ACR, SrCr, CrCl and eGFR were 0.06 +/- 0.38, 0.85 +/- 0.72 mg/dl, 129.85 +/- 50.37 ml/min and 99.18 +/- 25.69 ml/min/1.73 m(2) body surface area, respectively. All four CKD phenotypes exhibited significant heritabilities (P < 0.0001). A genome-wide scan showed linkage on chromosome 2p25 for SrCr, CrCl and eGFR. Significant linkage was also detected on chromosome 9q21 for eGFR [logarithm of the odds (LOD) score = 3.87, P = 0.00005] and SrCr (LOD score = 2.6, P = 0.00026). ACR revealed suggestive evidence for linkage to a region on chromosome 20q12 (LOD score = 2.93, P = 0.00020). CONCLUSION: Findings indicate that chromosomal regions 2p25, 9q21 and 20q12 may have functional relevance to CKD phenotypes in Mexican Americans. Twit Text FOAVip A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS ????Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=18443212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18443212 #FOAvip English Wikipedia <ref>{{Cite pmid|18443212}}</ref> A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS #MMPMID18443212 Arar NH; Voruganti VS; Nath SD; Thameem F; Bauer R; Cole SA; Blangero J; MacCluer JW; Comuzzie AG; Abboud HE Nephrol Dial Transplant 2008[Oct]; 23 (10): 3184-91 PMID18443212show ga BACKGROUND: Chronic kidney disease (CKD) phenotypes such as albuminuria measured by urinary albumin creatinine ratio (ACR), elevated serum creatinine (SrCr) and/or decreased creatinine clearance (CrCl) and glomerular filtration rate (eGFR) are major risk factors for renal and cardiovascular diseases. Epidemiological studies have reported that CKD phenotypes cluster in families suggesting a genetic predisposition. However, studies reporting chromosomal regions influencing CKD are very limited. Therefore, the purpose of this study is to identify susceptible chromosomal regions for CKD phenotypes in Mexican American families enrolled in the San Antonio Family Heart Study (SAFHS). METHODS: We used the variance components decomposition approach (implemented in the software package SOLAR) to perform linkage analysis on 848 participants from 26 families. A total of 417 microsatellite markers were genotyped at an average interval of 10 cM spanning 22 autosomal chromosomes. RESULTS: All phenotypes were measured by standard procedures. Mean +/- SD values of ACR, SrCr, CrCl and eGFR were 0.06 +/- 0.38, 0.85 +/- 0.72 mg/dl, 129.85 +/- 50.37 ml/min and 99.18 +/- 25.69 ml/min/1.73 m(2) body surface area, respectively. All four CKD phenotypes exhibited significant heritabilities (P < 0.0001). A genome-wide scan showed linkage on chromosome 2p25 for SrCr, CrCl and eGFR. Significant linkage was also detected on chromosome 9q21 for eGFR [logarithm of the odds (LOD) score = 3.87, P = 0.00005] and SrCr (LOD score = 2.6, P = 0.00026). ACR revealed suggestive evidence for linkage to a region on chromosome 20q12 (LOD score = 2.93, P = 0.00020). CONCLUSION: Findings indicate that chromosomal regions 2p25, 9q21 and 20q12 may have functional relevance to CKD phenotypes in Mexican Americans. |*Genetic Linkage[MESH] |Adolescent[MESH] |Adult[MESH] |Albuminuria/genetics[MESH] |Chromosomes, Human, Pair 2/genetics[MESH] |Chromosomes, Human, Pair 20/genetics[MESH] |Chromosomes, Human, Pair 9/genetics[MESH] |Creatinine/blood/urine[MESH] |Female[MESH] |Genetics, Population[MESH] |Glomerular Filtration Rate[MESH] |Humans[MESH] |Kidney Failure, Chronic/*genetics/physiopathology[MESH] |Lod Score[MESH] |Male[MESH] |Mexican Americans[MESH] |Microsatellite Repeats[MESH] |Middle Aged[MESH] |Risk Factors[MESH]A genome-wide search for linkage to chronic kidney disease in a commun(epmc).pdf DeepDyve Pubget Overpricing