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10.1038/nm1765 http://scihub22266oqcxt.onion/10.1038/nm1765 18438414!ä!18438414 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18438414&cmd=llinks): Failed to open stream: HTTP request failed! 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Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection |pdf=|usr=}}{{18438414}} gab.com Text Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=18438414 #FOAvip Secondary bacterial infection often occurs after pulmonary virus infection and is a common cause of severe disease in humans, yet the mechanisms responsible for this viral-bacterial synergy in the lung are only poorly understood. We now report that pulmonary interferon-gamma (IFN-gamma) produced during T cell responses to influenza infection in mice inhibits initial bacterial clearance from the lung by alveolar macrophages. This suppression of phagocytosis correlates with lung IFN-gamma abundance, but not viral burden, and leads to enhanced susceptibility to secondary pneumococcal infection, which can be prevented by IFN-gamma neutralization after influenza infection. Direct inoculation of IFN-gamma can mimic influenza infection and downregulate the expression of the class A scavenger receptor MARCO on alveolar macrophages. Thus, IFN-gamma, although probably facilitating induction of specific anti-influenza adaptive immunity, suppresses innate protection against extracellular bacterial pathogens in the lung. Twit Text FOAVip Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=18438414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18438414 #FOAvip English Wikipedia <ref>{{Cite pmid|18438414}}</ref> Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection #MMPMID18438414 Sun K; Metzger DW Nat Med 2008[May]; 14 (5): 558-64 PMID18438414show ga Secondary bacterial infection often occurs after pulmonary virus infection and is a common cause of severe disease in humans, yet the mechanisms responsible for this viral-bacterial synergy in the lung are only poorly understood. We now report that pulmonary interferon-gamma (IFN-gamma) produced during T cell responses to influenza infection in mice inhibits initial bacterial clearance from the lung by alveolar macrophages. This suppression of phagocytosis correlates with lung IFN-gamma abundance, but not viral burden, and leads to enhanced susceptibility to secondary pneumococcal infection, which can be prevented by IFN-gamma neutralization after influenza infection. Direct inoculation of IFN-gamma can mimic influenza infection and downregulate the expression of the class A scavenger receptor MARCO on alveolar macrophages. Thus, IFN-gamma, although probably facilitating induction of specific anti-influenza adaptive immunity, suppresses innate protection against extracellular bacterial pathogens in the lung. |Analysis of Variance[MESH] |Animals[MESH] |Bronchoalveolar Lavage Fluid/cytology/immunology[MESH] |CD4 Antigens/genetics/immunology[MESH] |CD8 Antigens/genetics/immunology[MESH] |Complement C3/genetics/immunology[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Immunity, Innate/drug effects/*immunology[MESH] |Interferon gamma Receptor[MESH] |Interferon-gamma/*immunology/pharmacology[MESH] |Interleukin-10/genetics/immunology[MESH] |Lung/drug effects/*immunology[MESH] |Macrophages/*drug effects/immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Microscopy, Fluorescence[MESH] |Orthomyxoviridae Infections/*immunology[MESH] |Pneumococcal Infections/*immunology[MESH] |Receptors, Immunologic/metabolism[MESH]Inhibition of pulmonary antibacterial defense by interferon-gamma duri(epmc).pdf DeepDyve Pubget Overpricing