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10.1208/s12249-008-9053-9 http://scihub22266oqcxt.onion/10.1208/s12249-008-9053-9 18431669/?report=reader!2976954!18431669     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+PharmSciTech 2008 ; 9 (2): 342-8 Nephropedia Template TP {{tp|p=18431669|t=2008. Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects |pdf=|usr=}}{{18431669}} gab.com Text Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects JO: AAPS PharmSciTech http://www.kidney.de/pget.php?&tw=1&pmid=18431669 #FOAvip The purpose of this research was to develop an emulsion formulation of indomethacin (IND) suitable for nasal delivery. IND was incorporated into the oil phases of oil in water (O/W) and water in oil (W/O) emulsions. For this purpose, different emulsifying agents (Tween 80, Span 80 and Brij 58) were used in two emulsion formulations. When the effects of several synthetic membranes (nylon, cellulose, cellulose nitrate) were compared with the sheep nasal mucosa, the cellulose membrane and sheep nasal mucosa showed similar permeation properties for O/W emulsion (P > 0.05). To examine the absorption characteristics of IND, the anti-inflammatory properties of intravenous solution of IND, intranasal O/W emulsions of IND (with or without enhancers) and intranasal solution of IND (IND-Sol) were investigated in rats with carrageenan-induced paw edema. When citric acid was added to the nasal emulsion, the anti-inflammatory activity was similar to that of intravenous solution (P > 0.05). Finally, it was concluded that, intranasal administration of IND emulsion with citric acid may be considered as an alternative to intravenous and per oral administrations of IND to overcome their adverse effects. Twit Text FOAVip Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects ????AAPS PharmSciTech http://www.kidney.de/pget.php?&tw=1&pmid=18431669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18431669 #FOAvip English Wikipedia <ref>{{Cite pmid|18431669}}</ref> Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects #MMPMID18431669 Karasulu HY; Sanal ZE; Sozer S; Guneri T; Ertan G AAPS PharmSciTech 2008[]; 9 (2): 342-8 PMID18431669show ga The purpose of this research was to develop an emulsion formulation of indomethacin (IND) suitable for nasal delivery. IND was incorporated into the oil phases of oil in water (O/W) and water in oil (W/O) emulsions. For this purpose, different emulsifying agents (Tween 80, Span 80 and Brij 58) were used in two emulsion formulations. When the effects of several synthetic membranes (nylon, cellulose, cellulose nitrate) were compared with the sheep nasal mucosa, the cellulose membrane and sheep nasal mucosa showed similar permeation properties for O/W emulsion (P > 0.05). To examine the absorption characteristics of IND, the anti-inflammatory properties of intravenous solution of IND, intranasal O/W emulsions of IND (with or without enhancers) and intranasal solution of IND (IND-Sol) were investigated in rats with carrageenan-induced paw edema. When citric acid was added to the nasal emulsion, the anti-inflammatory activity was similar to that of intravenous solution (P > 0.05). Finally, it was concluded that, intranasal administration of IND emulsion with citric acid may be considered as an alternative to intravenous and per oral administrations of IND to overcome their adverse effects. |Administration, Intranasal[MESH] |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage/chemistry/metabolism[MESH] |Carrageenan[MESH] |Cetomacrogol/chemistry[MESH] |Chemistry, Pharmaceutical[MESH] |Citric Acid/chemistry[MESH] |Disease Models, Animal[MESH] |Drug Compounding[MESH] |Edema/chemically induced/*prevention & control[MESH] |Emulsifying Agents/chemistry[MESH] |Emulsions[MESH] |Hexoses/chemistry[MESH] |Indomethacin/*administration & dosage/chemistry/metabolism[MESH] |Injections, Intravenous[MESH] |Male[MESH] |Membranes, Artificial[MESH] |Nasal Mucosa/*metabolism[MESH] |Permeability[MESH] |Polysorbates/chemistry[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Sheep[MESH] |Soybean Oil/*chemistry[MESH] |Time Factors[MESH]Permeation studies of indomethacin from different emulsions for nasal (epmc).pdf DeepDyve Pubget Overpricing