Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00424-008-0498-1 http://scihub22266oqcxt.onion/10.1007/s00424-008-0498-1 18431594!2518081!18431594     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pflugers+Arch 2008 ; 456 (6): 1005-24 Nephropedia Template TP {{tp|p=18431594|t=2008. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption |pdf=|usr=}}{{18431594}} gab.com Text Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption JO: Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=18431594 #FOAvip To prevent dehydration, terrestrial animals and humans have developed a sensitive and versatile system to maintain their water homeostasis. In states of hypernatremia or hypovolemia, the antidiuretic hormone vasopressin (AVP) is released from the pituitary and binds its type-2 receptor in renal principal cells. This triggers an intracellular cAMP signaling cascade, which phosphorylates aquaporin-2 (AQP2) and targets the channel to the apical plasma membrane. Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels. When water homeostasis is restored, AVP levels decline, and AQP2 is internalized from the plasma membrane, leaving the plasma membrane watertight again. The action of AVP is counterbalanced by several hormones like prostaglandin E2, bradykinin, dopamine, endothelin-1, acetylcholine, epidermal growth factor, and purines. Moreover, AQP2 is strongly involved in the pathophysiology of disorders characterized by renal concentrating defects, as well as conditions associated with severe water retention. This review focuses on our recent increase in understanding of the molecular mechanisms underlying AVP-regulated renal water transport in both health and disease. Twit Text FOAVip Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption ????Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=18431594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18431594 #FOAvip English Wikipedia <ref>{{Cite pmid|18431594}}</ref> Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption #MMPMID18431594 Boone M; Deen PM Pflugers Arch 2008[Sep]; 456 (6): 1005-24 PMID18431594show ga To prevent dehydration, terrestrial animals and humans have developed a sensitive and versatile system to maintain their water homeostasis. In states of hypernatremia or hypovolemia, the antidiuretic hormone vasopressin (AVP) is released from the pituitary and binds its type-2 receptor in renal principal cells. This triggers an intracellular cAMP signaling cascade, which phosphorylates aquaporin-2 (AQP2) and targets the channel to the apical plasma membrane. Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels. When water homeostasis is restored, AVP levels decline, and AQP2 is internalized from the plasma membrane, leaving the plasma membrane watertight again. The action of AVP is counterbalanced by several hormones like prostaglandin E2, bradykinin, dopamine, endothelin-1, acetylcholine, epidermal growth factor, and purines. Moreover, AQP2 is strongly involved in the pathophysiology of disorders characterized by renal concentrating defects, as well as conditions associated with severe water retention. This review focuses on our recent increase in understanding of the molecular mechanisms underlying AVP-regulated renal water transport in both health and disease. |Absorption[MESH] |Animals[MESH] |Aquaporin 2/biosynthesis/physiology[MESH] |Humans[MESH] |Kidney Diseases/metabolism/physiopathology[MESH] |Kidney/metabolism/*physiology/*physiopathology[MESH] |Signal Transduction/physiology[MESH] |Vasopressins/*physiology[MESH]Physiology and pathophysiology of the vasopressin-regulated renal wate(epmc).pdf DeepDyve Pubget Overpricing