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10.4049/jimmunol.180.9.6255 http://scihub22266oqcxt.onion/10.4049/jimmunol.180.9.6255 18424748!ä!18424748 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2008 ; 180 (9): 6255-61 Nephropedia Template TP {{tp|p=18424748|t=2008. Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses |pdf=|usr=}}{{18424748}} gab.com Text Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18424748 #FOAvip The innate immune response is essential for host defense against microbial pathogen infections and is mediated by pattern recognition molecules recognizing pathogen-associated molecular patterns. Our previous work has demonstrated that the extracellular matrix protein mindin functions as a pattern recognition molecule for bacterial pathogens. In this study, we examined the role of mindin in influenza virus infection. We found that intranasal infection of mindin-deficient mice by influenza virus resulted in dramatically increased virus titers in the lung and intranasal cavity of mutant mice. In contrast, lungs from intratracheally infected mindin-deficient mice contained similar influenza virus titers. We showed that mindin interacted with influenza virus particles directly and that mindin-deficient macrophages exhibited impaired activation after influenza virus infection in vitro. Furthermore, intranasal administration of recombinant mindin significantly enhanced the clearance of influenza virus in wild-type mice. Together, these results demonstrate that mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection. Twit Text FOAVip Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18424748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18424748 #FOAvip English Wikipedia <ref>{{Cite pmid|18424748}}</ref> Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses #MMPMID18424748 Jia W; Li H; He YW J Immunol 2008[May]; 180 (9): 6255-61 PMID18424748show ga The innate immune response is essential for host defense against microbial pathogen infections and is mediated by pattern recognition molecules recognizing pathogen-associated molecular patterns. Our previous work has demonstrated that the extracellular matrix protein mindin functions as a pattern recognition molecule for bacterial pathogens. In this study, we examined the role of mindin in influenza virus infection. We found that intranasal infection of mindin-deficient mice by influenza virus resulted in dramatically increased virus titers in the lung and intranasal cavity of mutant mice. In contrast, lungs from intratracheally infected mindin-deficient mice contained similar influenza virus titers. We showed that mindin interacted with influenza virus particles directly and that mindin-deficient macrophages exhibited impaired activation after influenza virus infection in vitro. Furthermore, intranasal administration of recombinant mindin significantly enhanced the clearance of influenza virus in wild-type mice. Together, these results demonstrate that mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection. |*Immunity, Innate/genetics[MESH] |Animals[MESH] |Dogs[MESH] |Extracellular Matrix Proteins/genetics/*immunology/pharmacology[MESH] |Influenza A Virus, H1N1 Subtype/*immunology[MESH] |Influenza A Virus, H3N2 Subtype/*immunology[MESH] |Lung/immunology/virology[MESH] |Macrophages/immunology/virology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Nasal Cavity/immunology/virology[MESH] |Orthomyxoviridae Infections/genetics/*immunology[MESH]Pattern recognition molecule mindin promotes intranasal clearance of i(epmc).pdf DeepDyve Pubget Overpricing