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10.1016/S1473-3099(08)70070-7 http://scihub22266oqcxt.onion/10.1016/S1473-3099(08)70070-7 18420459!7128266!18420459     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet+Infect+Dis 2008 ; 8 (9): 571-6 Nephropedia Template TP {{tp|p=18420459|t=2008. Confronting an influenza pandemic with inexpensive generic agents: can it be done?|pdf=|usr=}}{{18420459}} gab.com Text Confronting an influenza pandemic with inexpensive generic agents: can it be done JO: Lancet Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=18420459 #FOAvip Avian influenza A H5N1 presents a serious and possibly imminent pandemic threat. In such an event, adequate supplies of affordable vaccines and antiviral agents will be unavailable to most people in the world. In view of the overwhelming need for effective alternatives, generic agents that target the host immune response or the pandemic virus should be considered. Many scientists doubt the effectiveness of these agents. Nonetheless, several studies suggest that statins improve outcomes in patients with bacteraemia and pneumonia and might be similarly effective against influenza. An experimental study has shown that the fibrate gemfibrozil, a peroxisome proliferator-activated receptor (PPAR) alpha agonist, reduces mortality in H2N2 influenza virus-infected mice. There is substantial molecular cross-talk between statins and PPAR agonists, and their clinical effects are additive in patients with cardiovascular diseases. Chloroquine increases endosomal pH, impairing influenza virus release into the cytosol. Statins, fibrates, and chloroquine are produced as generic medications in developing countries. They are inexpensive, could be stockpiled, and would be available on the first pandemic day. With a lack of realistic alternatives for confronting the next pandemic, research is urgently needed to determine whether these and other generic agents could mitigate the effects of what might otherwise become an unprecedented global public-health crisis. Twit Text FOAVip Confronting an influenza pandemic with inexpensive generic agents: can it be done ????Lancet Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=18420459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18420459 #FOAvip English Wikipedia <ref>{{Cite pmid|18420459}}</ref> Confronting an influenza pandemic with inexpensive generic agents: can it be done? #MMPMID18420459 Fedson DS Lancet Infect Dis 2008[Sep]; 8 (9): 571-6 PMID18420459show ga Avian influenza A H5N1 presents a serious and possibly imminent pandemic threat. In such an event, adequate supplies of affordable vaccines and antiviral agents will be unavailable to most people in the world. In view of the overwhelming need for effective alternatives, generic agents that target the host immune response or the pandemic virus should be considered. Many scientists doubt the effectiveness of these agents. Nonetheless, several studies suggest that statins improve outcomes in patients with bacteraemia and pneumonia and might be similarly effective against influenza. An experimental study has shown that the fibrate gemfibrozil, a peroxisome proliferator-activated receptor (PPAR) alpha agonist, reduces mortality in H2N2 influenza virus-infected mice. There is substantial molecular cross-talk between statins and PPAR agonists, and their clinical effects are additive in patients with cardiovascular diseases. Chloroquine increases endosomal pH, impairing influenza virus release into the cytosol. Statins, fibrates, and chloroquine are produced as generic medications in developing countries. They are inexpensive, could be stockpiled, and would be available on the first pandemic day. With a lack of realistic alternatives for confronting the next pandemic, research is urgently needed to determine whether these and other generic agents could mitigate the effects of what might otherwise become an unprecedented global public-health crisis. |Antiviral Agents/pharmacology/*therapeutic use[MESH] |Chloroquine/pharmacology/therapeutic use[MESH] |Disease Outbreaks/*prevention & control[MESH] |Gemfibrozil/pharmacology/therapeutic use[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/therapeutic use[MESH] |Immunologic Factors/pharmacology/*therapeutic use[MESH] |Influenza A Virus, H5N1 Subtype/drug effects[MESH]Confronting an influenza pandemic with inexpensive generic agents: can(epmc).pdf DeepDyve Pubget Overpricing