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10.1016/j.ajem.2007.07.035

http://scihub22266oqcxt.onion/10.1016/j.ajem.2007.07.035
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18410827!ä!18410827

suck abstract from ncbi


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pmid18410827      Am+J+Emerg+Med 2008 ; 26 (4): 514.e1-3
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  • An under-recognized complication of treatment of acute severe asthma #MMPMID18410827
  • Creagh-Brown BC; Ball J
  • Am J Emerg Med 2008[May]; 26 (4): 514.e1-3 PMID18410827show ga
  • A 39-year-old man presented to the emergency department (ED) in severe respiratory distress. He had a prior diagnosis of brittle asthma and had been admitted on several occasions but never previously ventilated. Therapy given in the first 3 hours of arrival included nebulized salbutamol (5 mg, x5), ipratropium bromide (0.5 mg), intravenous hydrocortisone (200 mg), and magnesium sulfate (2 g). His arterial blood gases continued to deteriorate. He was then given an intravenous bolus of salbutamol (250 microg) and heliox via facemask. His worsening status necessitated invasive ventilation. His hypercapnia and resultant respiratory acidosis improved rapidly, but there was a concurrent accumulation of lactic acid resulting in acidemia. This patient had lactic acidosis as a direct effect of administration of salbutamol. The development of hazardous salbutamol-induced toxicity in acute severe asthma is discussed.
  • |Acidosis, Lactic/*chemically induced/therapy[MESH]
  • |Adult[MESH]
  • |Albuterol/*adverse effects[MESH]
  • |Anti-Asthmatic Agents/*adverse effects[MESH]
  • |Asthma/*drug therapy/therapy[MESH]
  • |Humans[MESH]
  • |Male[MESH]


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