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10.1158/0008-5472.CAN-07-5838 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-07-5838 18381407!2546565!18381407     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18381407&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18381407.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Res 2008 ; 68 (7): 2058-61 Nephropedia Template TP {{tp|p=18381407|t=2008. Cell cycle-dependent ciliogenesis and cancer |pdf=|usr=}}{{18381407}} gab.com Text Cell cycle-dependent ciliogenesis and cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=18381407 #FOAvip In mammals, most cell types have primary cilia, protruding structures involved in sensing mechanical and chemical signals from the extracellular environment that act as major communication hubs for signaling controlling cell differentiation and polarity. The list of clinical disorders associated with ciliary dysfunction has expanded from polycystic kidney disease to include many others. Transformed cells commonly lack cilia, but whether this lack is cause or consequence of transformation is not well understood. Here we discuss work addressing recently identified actions of the cancer-promoting proteins Aurora A and HEF1/NEDD9/CAS-L at cilia. Together with older studies, this work suggests that loss of cilia in cancer may contribute to the insensitivity of cancer cells to environmental repressive signals, based in part on derangement of cell cycle checkpoints governed by cilia and centrosomes. Twit Text FOAVip Cell cycle-dependent ciliogenesis and cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=18381407 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18381407 #FOAvip English Wikipedia <ref>{{Cite pmid|18381407}}</ref> Cell cycle-dependent ciliogenesis and cancer #MMPMID18381407 Plotnikova OV; Golemis EA; Pugacheva EN Cancer Res 2008[Apr]; 68 (7): 2058-61 PMID18381407show ga In mammals, most cell types have primary cilia, protruding structures involved in sensing mechanical and chemical signals from the extracellular environment that act as major communication hubs for signaling controlling cell differentiation and polarity. The list of clinical disorders associated with ciliary dysfunction has expanded from polycystic kidney disease to include many others. Transformed cells commonly lack cilia, but whether this lack is cause or consequence of transformation is not well understood. Here we discuss work addressing recently identified actions of the cancer-promoting proteins Aurora A and HEF1/NEDD9/CAS-L at cilia. Together with older studies, this work suggests that loss of cilia in cancer may contribute to the insensitivity of cancer cells to environmental repressive signals, based in part on derangement of cell cycle checkpoints governed by cilia and centrosomes. |Animals[MESH] |Cell Cycle/*physiology[MESH] |Cilia/metabolism/*physiology[MESH] |Humans[MESH]Cell cycle-dependent ciliogenesis and cancer (epmc).pdf DeepDyve Pubget Overpricing