Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


suck pdf from google scholar
unlimited free pdf from europmc18381407    free
PDF from PMC    free
html from PMC    free
PDF vom PMID18381407 :   free

suck abstract from ncbi

Nephropedia Template TP Text

Twit Text FOAVip

Twit Text #

English Wikipedia

  • Cell cycle-dependent ciliogenesis and cancer #MMPMID18381407
  • Plotnikova OV; Golemis EA; Pugacheva EN
  • Cancer Res 2008[Apr]; 68 (7): 2058-61 PMID18381407show ga
  • In mammals, most cell types have primary cilia, protruding structures involved in sensing mechanical and chemical signals from the extracellular environment that act as major communication hubs for signaling controlling cell differentiation and polarity. The list of clinical disorders associated with ciliary dysfunction has expanded from polycystic kidney disease to include many others. Transformed cells commonly lack cilia, but whether this lack is cause or consequence of transformation is not well understood. Here we discuss work addressing recently identified actions of the cancer-promoting proteins Aurora A and HEF1/NEDD9/CAS-L at cilia. Together with older studies, this work suggests that loss of cilia in cancer may contribute to the insensitivity of cancer cells to environmental repressive signals, based in part on derangement of cell cycle checkpoints governed by cilia and centrosomes.
  • |Animals[MESH]
  • |Cell Cycle/*physiology[MESH]
  • |Cilia/metabolism/*physiology[MESH]
  • |Humans[MESH]
  • |Neoplasms/metabolism/*pathology[MESH]

  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    2058 7.68 2008