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10.1007/s00109-008-0327-1 http://scihub22266oqcxt.onion/10.1007/s00109-008-0327-1 18335185!2374882!18335185     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Med+(Berl) 2008 ; 86 (6): 629-35 Nephropedia Template TP {{tp|p=18335185|t=2008. Involvement of (pro)renin receptor in the glomerular filtration barrier |pdf=|usr=}}{{18335185}} gab.com Text Involvement of (pro)renin receptor in the glomerular filtration barrier JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=18335185 #FOAvip (Pro)renin receptor-bound prorenin not only causes the generation of angiotensin II via the nonproteolytic activation of prorenin, it also activates the receptor's own intracellular signaling pathways independent of the generated angiotensin II. Within the kidneys, the (pro)renin receptor is not only present in the glomerular mesangium, it is also abundant in podocytes, which play an important role in the maintenance of the glomerular filtration barrier. Recent in vivo studies have demonstrated that the overexpression of the (pro)renin receptor to a degree similar to that observed in hypertensive rat kidneys leads to slowly progressive nephropathy with proteinuria. In addition, the handle region peptide, which acts as a decoy peptide and competitively inhibits the binding of prorenin to the receptor, is more beneficial than an angiotensin-converting enzyme inhibitor with regard to alleviating proteinuria and glomerulosclerosis in experimental animal models of diabetes and essential hypertension. Thus, the (pro)renin receptor may be upregulated in podocytes under hypertensive conditions and may contribute to the breakdown of the glomerular filtration barrier. Twit Text FOAVip Involvement of (pro)renin receptor in the glomerular filtration barrier ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=18335185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18335185 #FOAvip English Wikipedia <ref>{{Cite pmid|18335185}}</ref> Involvement of (pro)renin receptor in the glomerular filtration barrier #MMPMID18335185 Ichihara A; Sakoda M; Kurauchi-Mito A; Kaneshiro Y; Itoh H J Mol Med (Berl) 2008[Jun]; 86 (6): 629-35 PMID18335185show ga (Pro)renin receptor-bound prorenin not only causes the generation of angiotensin II via the nonproteolytic activation of prorenin, it also activates the receptor's own intracellular signaling pathways independent of the generated angiotensin II. Within the kidneys, the (pro)renin receptor is not only present in the glomerular mesangium, it is also abundant in podocytes, which play an important role in the maintenance of the glomerular filtration barrier. Recent in vivo studies have demonstrated that the overexpression of the (pro)renin receptor to a degree similar to that observed in hypertensive rat kidneys leads to slowly progressive nephropathy with proteinuria. In addition, the handle region peptide, which acts as a decoy peptide and competitively inhibits the binding of prorenin to the receptor, is more beneficial than an angiotensin-converting enzyme inhibitor with regard to alleviating proteinuria and glomerulosclerosis in experimental animal models of diabetes and essential hypertension. Thus, the (pro)renin receptor may be upregulated in podocytes under hypertensive conditions and may contribute to the breakdown of the glomerular filtration barrier. |Animals[MESH] |Diabetes Mellitus/metabolism[MESH] |Humans[MESH] |Hypertension/metabolism[MESH] |Kidney Glomerulus/*metabolism[MESH] |Prorenin Receptor[MESH] |Receptors, Cell Surface/*metabolism[MESH] |Renin/antagonists & inhibitors[MESH]Involvement of (pro)renin receptor in the glomerular filtration barrie(epmc).pdf DeepDyve Pubget Overpricing