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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Am+Soc+Nephrol 2008 ; 19 (12): 2272-5 Nephropedia Template TP
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Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis #MMPMID18322161
Thomson SC; Blantz RC
J Am Soc Nephrol 2008[Dec]; 19 (12): 2272-5 PMID18322161show ga
The homeostasis of NaCl is critical to complex organisms with closed blood systems. Kidneys regulate this salt excretion by modulating the rapport between glomeruli and tubules. The tubules respond to glomeruli with glomerulotubular balance, whereas glomeruli respond to tubules through tubuloglomerular feedback. These relationships are dynamic, mysterious, and amenable to mathematical analyses. The biology underlining what is known about these interactions is observational, fragmentary, and somewhat inconclusive. Discussed here is a simple tethering of these interrelated concepts.